Guajadial B

CAS# 1414455-03-0

Guajadial B

Catalog No. BCN3972----Order now to get a substantial discount!

Product Name & Size Price Stock
Guajadial B: 5mg $1150 In Stock
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Chemical structure

Guajadial B

3D structure

Chemical Properties of Guajadial B

Cas No. 1414455-03-0 SDF Download SDF
PubChem ID 71508109 Appearance Powder
Formula C30H34O5 M.Wt 474.6
Type of Compound Sesquiterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1=CCC(C=CCC2(C(CC1)C(C3=C(C(=C(C(=C3O2)C=O)O)C=O)O)C4=CC=CC=C4)C)(C)C
Standard InChIKey SCJBVAONMYLOHE-LUGVMUTJSA-N
Standard InChI InChI=1S/C30H34O5/c1-19-11-12-23-24(20-9-6-5-7-10-20)25-27(34)21(17-31)26(33)22(18-32)28(25)35-30(23,4)15-8-14-29(2,3)16-13-19/h5-10,13-14,17-18,23-24,33-34H,11-12,15-16H2,1-4H3/b14-8+,19-13+/t23-,24-,30+/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Guajadial B

The herbs of Psidium guajava

Biological Activity of Guajadial B

Description1. Guajadial B shows cytotoxicities against five human cancer cell lines, it is the most effective having an IC50 value of 150 nM toward A549 cells. 2. Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage.
TargetsTopoisomerase

Guajadial B Dilution Calculator

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Guajadial B Molarity Calculator

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Preparing Stock Solutions of Guajadial B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.107 mL 10.5352 mL 21.0704 mL 42.1408 mL 52.6759 mL
5 mM 0.4214 mL 2.107 mL 4.2141 mL 8.4282 mL 10.5352 mL
10 mM 0.2107 mL 1.0535 mL 2.107 mL 4.2141 mL 5.2676 mL
50 mM 0.0421 mL 0.2107 mL 0.4214 mL 0.8428 mL 1.0535 mL
100 mM 0.0211 mL 0.1054 mL 0.2107 mL 0.4214 mL 0.5268 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Guajadial B

Isolation and biomimetic synthesis of (+/-)-guajadial B, a novel meroterpenoid from Psidium guajava.[Pubmed:23163238]

Org Lett. 2012 Dec 7;14(23):5936-9.

(+/-)-Guajadial B (1), an unusual humulene-based meroterpenoid, was isolated as a racemate from the leaves of Psidium guajava, collected from Vietnam. The structure of this novel secondary metabolite was established on the basis of extensive analysis of NMR spectra and confirmed by biomimetic synthesis in a domino three-component coupling reaction.

Meroterpenoids with Antitumor Activities from Guava (Psidium guajava).[Pubmed:28578580]

J Agric Food Chem. 2017 Jun 21;65(24):4993-4999.

Psidium guajava L., a species native to South America, has been widely cultivated in the tropical and subtropical areas of China for its popular fruits. The preliminary analysis by liquid chromatography-ultraviolet (LC-UV) indicated the presence of meroterpenoids in the fruits of P. guajava (guava). Subsequent fractionation of the petroleum ether extract resulted in the identification of two new meroterpenoids, psiguajavadials A (1) and B (2), together with 14 previously described meroterpenoids (3-16). Their structures were fully elucidated by comprehensive spectroscopic techniques and theoretical calculations. All of the meroterpenoids showed cytotoxicities against five human cancer cell lines, with Guajadial B (12) being the most effective having an IC50 value of 150 nM toward A549 cells. Furthermore, biochemical topoisomerase I (Top1) assay revealed that psiguajavadial A (1), psiguajavadial B (2), Guajadial B (12), guajadial C (14), and guajadial F (16) acted as Top1 catalytic inhibitors and delayed Top1 poison-mediated DNA damage. The flow cytometric analysis indicated that the new meroterpenoids psiguajavadials A (1) and B (2) could induce apoptosis of HCT116 cells. These data suggest that meroterpenoids from guava fruit could be used for the development of antitumor agents.

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