Guajadial BCAS# 1414455-03-0 |
- Epiguajadial B
Catalog No.:BCN4075
CAS No.:1411629-26-9
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1414455-03-0 | SDF | Download SDF |
| PubChem ID | 71508109 | Appearance | Powder |
| Formula | C30H34O5 | M.Wt | 474.6 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1=CCC(C=CCC2(C(CC1)C(C3=C(C(=C(C(=C3O2)C=O)O)C=O)O)C4=CC=CC=C4)C)(C)C | ||
| Standard InChIKey | SCJBVAONMYLOHE-LUGVMUTJSA-N | ||
| Standard InChI | InChI=1S/C30H34O5/c1-19-11-12-23-24(20-9-6-5-7-10-20)25-27(34)21(17-31)26(33)22(18-32)28(25)35-30(23,4)15-8-14-29(2,3)16-13-19/h5-10,13-14,17-18,23-24,33-34H,11-12,15-16H2,1-4H3/b14-8+,19-13+/t23-,24-,30+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Guajadial B shows cytotoxicities against five human cancer cell lines, it is the most effective having an IC50 value of 150 nM toward A549 cells. 2. Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. |
| Targets | Topoisomerase |
Guajadial B Dilution Calculator
Guajadial B Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.107 mL | 10.5352 mL | 21.0704 mL | 42.1408 mL | 52.6759 mL |
| 5 mM | 0.4214 mL | 2.107 mL | 4.2141 mL | 8.4282 mL | 10.5352 mL |
| 10 mM | 0.2107 mL | 1.0535 mL | 2.107 mL | 4.2141 mL | 5.2676 mL |
| 50 mM | 0.0421 mL | 0.2107 mL | 0.4214 mL | 0.8428 mL | 1.0535 mL |
| 100 mM | 0.0211 mL | 0.1054 mL | 0.2107 mL | 0.4214 mL | 0.5268 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Diosgenin glucoside
Catalog No.:BCN1250
CAS No.:14144-06-0
- ABT-751 (E7010)
Catalog No.:BCC1085
CAS No.:141430-65-1
- MRS 2219
Catalog No.:BCC6966
CAS No.:14141-47-0
- PX 12
Catalog No.:BCC2436
CAS No.:141400-58-0
- Trachelanthamine
Catalog No.:BCN2041
CAS No.:14140-18-2
- Orobanchyl acetate
Catalog No.:BCN7779
CAS No.:1413843-71-6
- PEPA
Catalog No.:BCC5951
CAS No.:141286-78-4
- QS-21
Catalog No.:BCC8243
CAS No.:141256-04-4
- Asenapine hydrochloride
Catalog No.:BCC1371
CAS No.:1412458-61-7
- Btk inhibitor 1
Catalog No.:BCC4238
CAS No.:1412418-47-3
- 2-(Dimethylaminomethyl)-2-propanol
Catalog No.:BCN1774
CAS No.:14123-48-9
- Epiguajadial B
Catalog No.:BCN4075
CAS No.:1411629-26-9
- Rauvoyunine A
Catalog No.:BCN7002
CAS No.:1414883-81-0
- Rauvoyunine B
Catalog No.:BCN6995
CAS No.:1414883-82-1
- Aloin A
Catalog No.:BCN1042
CAS No.:1415-73-2
- Levosimendan
Catalog No.:BCC4793
CAS No.:141505-33-1
- 5S rRNA modificator
Catalog No.:BCC5442
CAS No.:1415238-77-5
- Pelandjauic acid
Catalog No.:BCN3752
CAS No.:141545-69-9
- LY 231617
Catalog No.:BCC7005
CAS No.:141545-89-3
- MK-8245 Trifluoroacetate
Catalog No.:BCC1769
CAS No.:1415559-41-9
- CDK9 inhibitor
Catalog No.:BCC1465
CAS No.:1415559-43-1
- GSK256066 2,2,2-trifluoroacetic acid
Catalog No.:BCC1605
CAS No.:1415560-64-3
- Crizotinib hydrochloride
Catalog No.:BCC5306
CAS No.:1415560-69-8
- PF-543
Catalog No.:BCC1854
CAS No.:1415562-82-1
Isolation and biomimetic synthesis of (+/-)-guajadial B, a novel meroterpenoid from Psidium guajava.[Pubmed:23163238]
Org Lett. 2012 Dec 7;14(23):5936-9.
(+/-)-Guajadial B (1), an unusual humulene-based meroterpenoid, was isolated as a racemate from the leaves of Psidium guajava, collected from Vietnam. The structure of this novel secondary metabolite was established on the basis of extensive analysis of NMR spectra and confirmed by biomimetic synthesis in a domino three-component coupling reaction.
Meroterpenoids with Antitumor Activities from Guava (Psidium guajava).[Pubmed:28578580]
J Agric Food Chem. 2017 Jun 21;65(24):4993-4999.
Psidium guajava L., a species native to South America, has been widely cultivated in the tropical and subtropical areas of China for its popular fruits. The preliminary analysis by liquid chromatography-ultraviolet (LC-UV) indicated the presence of meroterpenoids in the fruits of P. guajava (guava). Subsequent fractionation of the petroleum ether extract resulted in the identification of two new meroterpenoids, psiguajavadials A (1) and B (2), together with 14 previously described meroterpenoids (3-16). Their structures were fully elucidated by comprehensive spectroscopic techniques and theoretical calculations. All of the meroterpenoids showed cytotoxicities against five human cancer cell lines, with Guajadial B (12) being the most effective having an IC50 value of 150 nM toward A549 cells. Furthermore, biochemical topoisomerase I (Top1) assay revealed that psiguajavadial A (1), psiguajavadial B (2), Guajadial B (12), guajadial C (14), and guajadial F (16) acted as Top1 catalytic inhibitors and delayed Top1 poison-mediated DNA damage. The flow cytometric analysis indicated that the new meroterpenoids psiguajavadials A (1) and B (2) could induce apoptosis of HCT116 cells. These data suggest that meroterpenoids from guava fruit could be used for the development of antitumor agents.
