Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 31

  1. Cat.No. Product Name Information/Activity
  2. BCC5226 UK 14,304 Brimonidine (UK 14304) is a full α2-adrenergic receptor (α2-AR) agonist. UK 14,304 chemical structure
  3. BCC7336 A 80426 mesylate 152148-64-6 A 80426 mesylate chemical structure
  4. BCC6851 ARC 239 dihydrochloride 55974-42-0 ARC 239 dihydrochloride chemical structure
  5. BCC7521 Atipamezole hydrochloride Atipamezole hydrochloride is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM. Atipamezole hydrochloride chemical structure
  6. BCC6948 BRL 44408 maleate 681806-46-2 BRL 44408 maleate chemical structure
  7. BCC6797 Efaroxan hydrochloride 89197-00-2 Efaroxan hydrochloride chemical structure
  8. BCC6798 Idazoxan hydrochloride Idazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like drugs (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism. Idazoxan hydrochloride chemical structure
  9. BCC6875 Imiloxan hydrochloride 81167-22-8 Imiloxan hydrochloride chemical structure
  10. BCC7449 JP 1302 dihydrochloride JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Kb value (antagonist activity) of 16 nM and a Ki (binding affinity) value of 28 nM. JP 1302 dihydrochloride chemical structure
  11. BCC4923 Mirtazapine Mirtazapine is a 5-HT receptor inhibitor. Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent by blocking 5-HT2 and 5-HT3 receptors. Mirtazapine chemical structure

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