Pain and Inflammation Research

Although separate conditions, pain and inflammation are nearly always associated with each other. Pain is defined by the International Association for the Study of Pain (IASP) as 'an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage'. Inflammation is the tissue's immunologic response to injury, characterized by mobilization of white blood cells and antibodies, swelling, and fluid accumulation.

Pain and Inflammation Research Products Areas

Products for Pain and Inflammation Research - Page 32

Cat.No. Product Name Information/Activity
BCC1234 Calpain Inhibitor II, ALLM Cathepsin inhibitor,Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.
BCC1141 CA 074 CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
BCC2350 Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor
BCC2351 Calpeptin Calpeptin is a potent, cell penetrating calpain inhibitor, with an ID50 of 40 nM for Calpain I in human platelets. Calpeptin is also an inhibitor of cathepsin K.
BCC1222 E-64 E-64 (Proteinase inhibitor E 64) is a potent irreversible inhibitor against general cysteine proteases with IC50 of 9 nM for papain.
BCC1127 E 64d Aloxistatin (E64d) is a cell-permeable and irreversible broad-spectrum cysteine protease inhibitor.
BCC2361 L 006235 Potent cathepsin K inhibitor
BCC2352 MDL 28170 MDL-28170 (Calpain Inhibitor III) is a potent, selective and membrane-permeable cysteine protease inhibitor of calpain that rapidly penetrates the blood-brain barrier following systemic administration. MDL-28170 also block γ-secretase.
BCC1233 Calpain Inhibitor I, ALLN MG-101 is a potent inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively.
BCC2353 PD 150606 PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor with Ki values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective.