Products for CYP3A/CYP450
- Cat.No. Product Name Information
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BCC2271
Cobicistat (GS-9350)
Cobicistat is a potent and selective inhibitor of cytochrome P450 3A (CYP3A) enzymes with IC50s of 30-285 nM. Cobicistat is a pharmacokinetic enhancer which increases the overall absorption of several HIV medications.
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BCC5406
Dafadine-A
Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1).
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BCC7979
3-Cyano-7-ethoxycoumarin
3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage Target: Cytochrome P450 3-Cyano-7-ethoxycoumarin is a fluorescent probe useful in microsomal dealkylase studies.
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BCC5399
VT-464 racemate
Seviteronel racemate (VT-464 racemate) is the racemate form of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=nM)inhibition.
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BCC6002
YM 511
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BCC5398
VT-464
Seviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition.
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BCC7998
ABT
1-Aminobenzotriazole is a nonspecific and irreversible inhibitor of cytochrome P450 (P450).
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BCC7093
TMS
TMS is a selective inhibitor of CYP1B1 activity.
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BCN2356
Diosmetin
Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.
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BCC6296
Methoxyresorufin
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BCC6476
7-Ethoxyresorufin
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BCC6297
Pentoxyresorufin
