Dafadine-ADAF-9 cytochrome P450 inhibitor CAS# 1065506-69-5 |
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Quality Control & MSDS
3D structure
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| Cas No. | 1065506-69-5 | SDF | Download SDF |
| PubChem ID | 24790866 | Appearance | Powder |
| Formula | C23H25N3O3 | M.Wt | 391.46 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 50 mg/mL (127.73 mM; Need ultrasonic) | ||
| Chemical Name | [5-[(2,6-dimethylphenoxy)methyl]-1,2-oxazol-3-yl]-(4-pyridin-4-ylpiperidin-1-yl)methanone | ||
| SMILES | CC1=C(C(=CC=C1)C)OCC2=CC(=NO2)C(=O)N3CCC(CC3)C4=CC=NC=C4 | ||
| Standard InChIKey | WNSNPYIHDMIFOO-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C23H25N3O3/c1-16-4-3-5-17(2)22(16)28-15-20-14-21(25-29-20)23(27)26-12-8-19(9-13-26)18-6-10-24-11-7-18/h3-7,10-11,14,19H,8-9,12-13,15H2,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Dafadine-A Dilution Calculator
Dafadine-A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.5545 mL | 12.7727 mL | 25.5454 mL | 51.0908 mL | 63.8635 mL |
| 5 mM | 0.5109 mL | 2.5545 mL | 5.1091 mL | 10.2182 mL | 12.7727 mL |
| 10 mM | 0.2555 mL | 1.2773 mL | 2.5545 mL | 5.1091 mL | 6.3863 mL |
| 50 mM | 0.0511 mL | 0.2555 mL | 0.5109 mL | 1.0218 mL | 1.2773 mL |
| 100 mM | 0.0255 mL | 0.1277 mL | 0.2555 mL | 0.5109 mL | 0.6386 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Dafadine-A is a small-molecule and novel inhibitor of DAF-9 cytochrome P450 (CYP27A1) [1].
Dafadine-A has been reported to induce loss of function of DAF-9 and alteration in the ligand-binding domain of DAF-12 in mammalian.. It can inhibit the enzymatic activity of DAF-9 in cells. The production of dafachronic acids was antagonized by dafadine-A. The absorbance spectroscopy studies showed that dafadine-A altered the difference spectrum of microsome-associated DAF-9 with a type 2 spectrum. These results suggested that dafadine-A is physically tethered to the catalytic center of the DAF-9. [1].
References:
[1]. Luciani GM1, Magomedova L, Puckrin R, Urbanus ML, Wallace IM, Giaever G, Nislow C, Cummins CL, Roy PJ. Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Nat Chem Biol. 2011 Nov 6;7(12):891-3.
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Dafadine-A, an analog of dafadine, is a novel inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans; also inhibits the mammalian ortholog of DAF-9(CYP27A1).
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