7-Amino-4-methylcoumarin-3-acetic acidCAS# 106562-32-7 |
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| Cas No. | 106562-32-7 | SDF | Download SDF |
| PubChem ID | 129367 | Appearance | Cryst. |
| Formula | C12H11NO4 | M.Wt | 233.22 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Synonyms | 7-Amino-4-Methyl-3-Coumarinylacetic Acid | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 2-(7-amino-4-methyl-2-oxochromen-3-yl)acetic acid | ||
| SMILES | CC1=C(C(=O)OC2=C1C=CC(=C2)N)CC(=O)O | ||
| Standard InChIKey | QEQDLKUMPUDNPG-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C12H11NO4/c1-6-8-3-2-7(13)4-10(8)17-12(16)9(6)5-11(14)15/h2-4H,5,13H2,1H3,(H,14,15) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Guazuma ulmifolia
| Description | 1. 7-Amino-4-methylcoumarin is more suitable as a substrate for enteropeptidase than GD(4)K-NA. |
7-Amino-4-methylcoumarin-3-acetic acid Dilution Calculator
7-Amino-4-methylcoumarin-3-acetic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.2878 mL | 21.439 mL | 42.878 mL | 85.7559 mL | 107.1949 mL |
| 5 mM | 0.8576 mL | 4.2878 mL | 8.5756 mL | 17.1512 mL | 21.439 mL |
| 10 mM | 0.4288 mL | 2.1439 mL | 4.2878 mL | 8.5756 mL | 10.7195 mL |
| 50 mM | 0.0858 mL | 0.4288 mL | 0.8576 mL | 1.7151 mL | 2.1439 mL |
| 100 mM | 0.0429 mL | 0.2144 mL | 0.4288 mL | 0.8576 mL | 1.0719 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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A fluorogenic method for measuring enteropeptidase activity: spectral shift in the emission of GD4K-conjugated 7-amino-4-methylcoumarin.[Pubmed:21777516]
BMB Rep. 2011 Jul;44(7):458-61.
Enteropeptidase is a serine protease secreted by the pancreas and converts inactive trypsinogen to active trypsin. Enteropeptidase cleaves the C-terminal end of the substrate recognition sequence Asp-Asp-Asp-Asp-Lys (D(4)K). The assay for enteropeptidase has utilized GD(4)K-conjugated 2-naphthylamine (GD(4)K-NA) as a fluorogenic probe over the last 30 years. However, no other D(4)K-conjugated fluorogenic substrates of enteropeptidase have been reported. Furthermore, naphthalene is known as carcinogenic to humans. In this study, we used shift in the emission spectrum of GD(4)K-conjugated 7-amino-4-methylcoumarin (GD(4)K-AMC) as a fluorogenic method to measure enteropeptidase activity. The kinetic analysis revealed that enteropeptidase has a K(M) of 0.025 mM and a k(cat) of 65 sec(-1) for GD(4)K-AMC, whereas it has a K(M) of 0.5 to 0.6 mM and a k(cat) of 25 sec(-1) for GD(4)K-NA. The optimum pH of GD(4)K-AMC hydrolysis was pH 8.0. Our data indicate that GD(4)K-AMC is more suitable as a substrate for enteropeptidase than GD(4)K-NA.
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