Products with Anticancer bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6120 | Bulleyanin |
| 1. Bulleyanin shows strong inhibition of mouse ehrlich ascites carcinoma (ECA), mouse sarcoma S-180, and mouse liver ascites. | |
| BCN6127 | Cannabidiolic acid |
| 1. Cannabidiolic acid (CBDA) inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA; it offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers. 2. Cannabidiolic acid displays significantly greater potency at inhibiting vomiting in shrews and nausea in rats, and at enhancing 5-HT(1A) receptor activation, an action that accounts for its ability to attenuate conditioned gaping in rats. 3. Cannabidiolic acid selectively inhibits cyclooxygenase (COX)-2 activity with an IC(50) value around 2 microM, has 9-fold higher selectivity than COX-1 inhibition. 4. Cannabidiolic acid and cannabidiol have inhibitory actions on the intestines of S. murinus that are not neuronallymediated or mediated via CB1 or CB2 receptors. | |
| BCN6148 | Taraxerol |
| 1. Taraxerol has potent anti-inflammatory effects,it downregulates the expression of proinflammatory mediators in macrophages by interfering with the activation of TAK1 and Akt, thus preventing NF-κB activation. 2. Taraxerol can produce triterpenoid anti-cancer compound in Agrobacterium-transformed root cultures of butterfly pea (Clitoria ternatea L.). 3. Taraxerol can be used as a lipid biomarker for mangrove input to the SE Atlantic. 4. Taraxerol has inhibitory effects on AGS cell growth through inducing G2/M arrest and promotion of cell apoptosis, taraxeryl acetate has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol. | |
| BCN6160 | Paulownin |
| 1. (+)-Paulownin is active against the MCF-7 breast cancer cell line with IC50 values of 14.0 uM. 2. Paulownin has the action of anti-inflammation,analgesia,immunity,hypoglycemia and has little toxicity. 3. Paulownin demonstrates inhibitory activities against H. pylori Cystathionine gamma- synthase (HpCGS) with IC50 values of 19 +/- 2 microM, it can highly inhibit the growth of H. pylori and exhibit strong inhibitory specificity against H. pylori related to E. coli. | |
| BCN6161 | alpha-Terthienylmethanol |
| 1. Alpha-terthienylmethanol possesses potent cytotoxic activity against human endometrial cancer cells. 2. Alpha-terthienylmethanol inhibits growth mediated by the induction of apoptosis, as shown by the accumulation of sub-G1 and apoptotic cells. | |
