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BCN6319 |
Berberine hydrochloride
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Berberine hydrochloride has anticancer, antifungi, anti-inflammatory, and anti-oxidant activities, it can significantly attenuate neutrophil infiltration, suppress myeloperoxidase activity, decrease NO, TNF-αand IL-1βproduction, inhibits the phosphorylation of the NF-κB p65 subunit and the degradation of its inhibitor, IκBα. |
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BCN6320 |
Coptisine
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Coptisine is an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM, it can consequently prevent neuron loss, reduce amyloid plaque formation, and ameliorate impaired cognition, it could as a potential new class of drugs for AD treatment. Coptisine has cardioprotection, anti- hypercholesterolemia, anti-fungal, anti-osteosarcoma, anti-hepatoma and anti-leukaemia activities, it also has antispasmodic and relaxant activity on a guinea-pig ileum. |
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BCN6326 |
(-)-Epigallocatechin gallate
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(-)-Epigallocatechin Gallate is an antioxidant polyphenol flavonoid form green tea, and inhibits the activation of EGFR, HER2 and HER3, with antitumor activity. (-)-Epigallocatechin gallate treatment enduring to cardio protection at mitochondrial level, it has protective effects against βA-induced neuronal apoptosis through scavenging reactive oxygen species, which may be beneficial for the prevention of Alzheimer's disease. |
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BCN6331 |
Isoliensinine
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Isoliensinine has anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities, it inhibited TNF-alpha and TGF-beta 1; decreased the overexpression of growth factors Platelet-derived growth factor (PDGF)-beta, basic fibroblast growth factor (bFGF), proto-oncogene c-fos, c-myc and hsp70; and activated ROS and p38 MAPK/JNK . |
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BCN6333 |
Licochalcone B
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Licochalcone B has antitumor, antimetastatic, cardioprotective, antioxidant, antiapoptotic, and anti-inflammatory effects, it can significantly inhibit LPS-induced phosphorylation at serine 276 and transcriptional activation of NF-KB. Licochalcone B can protect the liver from carbon tetrachloride (CCl4)-induced injury, the protection may be due to inhibition of p38 and NFκB signaling, which subsequently reduces inflammation in the liver. |
