Products with Anticancer bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6165 | Protopine |
| Protopine acts as a potent inhibitor of thromboxane synthesis and PAF with hepatoprotective, antidepressant, antioxidant, antispasmodic and relaxant properties. Protopine is also a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Protopine blocks phosphorylation of mitogen-activated protein kinases (MAP kinases) and also blocks activation of a nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). | |
| BCN6172 | 4-Epialyxialactone |
| 1. 4-Epialyxialactone exhibits significant antitumor and antibacterial activity. | |
| BCN6197 | Pomolic acid |
| Pomolic acid has anti-cancer, anti-inflammatory and apoptotic activities, it can induce apoptosis in SK-OV-3 cells, which is mediated by the mitochondrial-mediated intrinsic and death receptor-induced extrinsic pathways. Pomolic acid is a potent inhibitor of the aggregation of human platelets induced by ADP and Epinephrine, exhibits IC50 values close to 60 nM and 20 nM, respectively; pomolic acid does not inhibit human platelet aggregation induced by PAF, collagen, U46619 (thromboxane analogue), TRAP or arachidonic acid; suggests that the hypotensive and platelet anti-aggregating effects of pomolic acid and its potential role in cardiovascular therapy. | |
| BCN6198 | Tormentic acid |
| 1. Tormentic acid has anti-allodynic action, can inhibit markedly the neuropathic allodynia induced by partial ligation of the sciatic nerve. 2. Tormentic acid has anti-inflammatory activity, it potently inhibits the production of nitric oxide (NO) in RAW 264.7 cells, also suppresses the LPS-stimulated degradation and phosphorylation of inhibitor of kappa B-α (IκB-α), suggests that the anti-inflammatory activity of TA is associated with the down-regulation of iNOS, COX-2, and TNF-α through the negative regulation of the NF-κB pathway in RAW 264.7 cells. 3. Tormentic acid has anticancer, anti-atherogenic properties and minimal toxicity in vivo, it also can reduce vascular smooth muscle cell proliferation and survival. 4. Tormentic acid has protective effect against lipopolysaccharide/D-galactosamine induced fulminant hepatic failure in mice. | |
| BCN6202 | Isocoronarin D |
| 1. Isocoronarin D shows the highest Hb F induction effect of 1.6-fold at 20 microM. 2. Isocoronarin D can activate antioxidant response element (ARE) (EC50 57.6 ± 2.4 uM), it may have potential chemopreventive activity. 3. Isocoronarin D is a main active ingredient for inducing death of the tested cancer cells, it possesses a wide anti-cancer capability. | |
