Products with Antifungal bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2539 | Pterostilbene |
| Pterostilbene acts as a peroxisome proliferator-activated receptor alpha (PPARalpha) agonist, it has been implicated in anticarcinogenesis, antioxidant, modulation of neurological disease, anti-inflammation, attenuation of vascular disease, and amelioration of diabetes. Pterostilbene downregulates inflammatory iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NFkappaB by interfering with the activation of PI3K/Akt/IKK and MAPK. Pterostilbene may protect HUVECs against oxLDL-induced apoptosis by downregulating LOX-1-mediated activation through a pathway involving oxidative stress, p53, mitochondria, cytochrome c and caspase protease. | |
| BCN2564 | Amphotericin B |
| 1. Amphotericin B is an antifungal agent. 2. Amphotericin B inhibits the A. actinomycetemcomitans-induced production of prostaglandin E2. 3. Amphotericin B can regulate inflammatory cytokines in host cells and regulate inflammatory responses in HGEC. 4. Amphotericin B inhibits the A. actinomycetemcomitans-induced phosphorylation of ERK and p38 MAP kinase. 5. The inhibition of the PKA signaling pathway can aid in reducing the degree of nephrotoxicity caused by Amphotericin B. 6. Treatment with Amphotericin B, particularly in combination with MCSF, increased the number of oligodendrocyte precursor cells and promoted remyelination within lesions. | |
| BCN2586 | Plumbagin |
| Plumbagin, a potential natural FOXM1 inhibitor, has anticancer, and anti-fibrotic activies, it inactivates the NF-κB/TLR-4 pathway that is associated with inflammatory reactions, thereby mitigating liver fibrosis. Plumbagin offers significant protective role against DEX-induced cellular damage via regulating oxidative stress, apoptosis, and osteogenic markers. | |
| BCN2618 | Anisic aldehyde |
| Anisic aldehyde is a safe food additive for human, it has significant antifungal activity against Candida, including azole-resistant strains. | |
| BCN2633 | 5-Isopropyl-2-methylphenol |
| 5-Isopropyl-2-methylphenol presents anxiolytic, antinociceptive, and antidepressant effects, it seems to be dependent on its interaction with the dopaminergic system, but not with the serotonergic and noradrenergic systems. | |
