Products with Antifungal bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6579 | Xanthoxyletin |
| 1. Xanthoxyletin shows cytotoxic activity, it can inhibit the incorporation of tritiated thymidine into human leukaemia (HL-60) cells. 2. Xanthoxyletin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells, the effects are associated with the DNA damage, apoptosis through mitochondrial dysfunction, and cell cycle arrest at S phase in a dose-dependent manner, it also can increase the production of reactive oxygen species, suggest that xanthoxyletin may be promising anticancer agent. 3. Xanthoxyletin shows anti-inflammatory activities, it shows an inhibitory effect on iNOS protein expression at 10 microM, it also can inhibit the synthesis of nitric oxide and the protein expression of tumor necrosis factor-alpha and cyclooxygenase-2 . 4. Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties. | |
| BCN6613 | Chloramultilide B |
| 1.Chloramultilide B exhibits moderate in vitro antifungal activity. | |
| BCN6660 | Taxoquinone |
| 1. Taxoquinone shows significant and concentration-dependent antioxidant and free radical scavenging activities of DPPH, nitric oxide, superoxide and hydroxyl free radicals by 78.83%, 72.42%, 72.99% and 85.04%, as compared to standard compounds ascorbic acid (81.69%, 74.62%, 73% and 73.79%). 2. Taxoquinone at the concentration range of 100-3,000 ug/mL and 200-1,000 ug/mL shows potent efficacy on inhibiting α-glucosidase and tyrosinase enzymes by 9.24-51.32% and 11.14-52.32%, respectively; suggests that taxoquinone could as a novel candidate in food and medicine industry as a natural alternative medicine to prevent diabetes mellitus type-2 related disorders and as a depigmentation agent. 3. Taxoquinone (100 ug/disc) displays potential anticandidal effect against Candia albicans. 4. Taxoquinone has strong antibacterial effect, it could be used as a promising antibacterial agent in food industry to inhibit the growth of certain important foodborne pathogens. | |
| BCN6695 | Licoisoflavone B |
| 1. Licoisoflavone B exhibits antimutagenic activity against carcinogenic N-methyl-N-nitrosourea (MNU), it is important to prevent DNA damage by N-nitrosamines for cancer chemoprevention. 2. Licoisoflavone B is an inhibitor of germ tube growth in the arbuscular mycorrhizal (AM) fungus Gigaspora margarita, it can strongly inhibit germ tube growth at 0.63 ug/disc, and it can completely inhibit hyphal branching induced by a lupin strigolactone, orobanchyl acetate, in G. margarita at 0.16 ug/disc. 3. Licoisoflavone B exhibits inhibitory activity against the growth of Helicobacter pylori in vitro, it also shows anti-H. pylori activity against a clarithromycin (CLAR) and amoxicillin (AMOX)-resistant strain. 4. Licoisoflavones A and B show inhibitory effects on copper-ion-induced protein oxidative modification of mice brain homogenate, in vitro. | |
| BCN6796 | Mosloflavone |
| 1. Mosloflavanone is an antifungal and radical scavenging 2-hydroxyflavanone. 2. Mosloflavone possesses strong anti-EV71 activity and decreased the formation of visible cytopathic effects, it also inhibits virus replication during the initial stage of virus infection, and inhibits viral VP2 protein expression, thereby inhibiting viral capsid protein synthesis. 3. Mosloflavone can significantly prolong the survival time of hypoxic mice. 4. Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 uM and 6.4 uM, respectively; it shows dose-dependent inhibition of TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A. 5. Mosloflavone can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases. | |
