MosloflavoneCAS# 740-33-0 |
Quality Control & MSDS
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| Cas No. | 740-33-0 | SDF | Download SDF |
| PubChem ID | 471722 | Appearance | Yellow powder |
| Formula | C17H14O5 | M.Wt | 298.3 |
| Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 5-hydroxy-6,7-dimethoxy-2-phenylchromen-4-one | ||
| SMILES | COC1=C(C(=C2C(=C1)OC(=CC2=O)C3=CC=CC=C3)O)OC | ||
| Standard InChIKey | SIVAITYPYQQYAP-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C17H14O5/c1-20-14-9-13-15(16(19)17(14)21-2)11(18)8-12(22-13)10-6-4-3-5-7-10/h3-9,19H,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Mosloflavanone is an antifungal and radical scavenging 2-hydroxyflavanone. 2. Mosloflavone possesses strong anti-EV71 activity and decreased the formation of visible cytopathic effects, it also inhibits virus replication during the initial stage of virus infection, and inhibits viral VP2 protein expression, thereby inhibiting viral capsid protein synthesis. 3. Mosloflavone can significantly prolong the survival time of hypoxic mice. 4. Mosloflavone shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 16.4 uM and 6.4 uM, respectively; it shows dose-dependent inhibition of TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A. 5. Mosloflavone can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases. |
| Targets | TNF-α | IL Receptor | NOS | Antifection |
Mosloflavone Dilution Calculator
Mosloflavone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.3523 mL | 16.7616 mL | 33.5233 mL | 67.0466 mL | 83.8082 mL |
| 5 mM | 0.6705 mL | 3.3523 mL | 6.7047 mL | 13.4093 mL | 16.7616 mL |
| 10 mM | 0.3352 mL | 1.6762 mL | 3.3523 mL | 6.7047 mL | 8.3808 mL |
| 50 mM | 0.067 mL | 0.3352 mL | 0.6705 mL | 1.3409 mL | 1.6762 mL |
| 100 mM | 0.0335 mL | 0.1676 mL | 0.3352 mL | 0.6705 mL | 0.8381 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Chemical Constituents with Anti-hypoxia Activity from Saussurea involucrata].[Pubmed:26214875]
Zhong Yao Cai. 2015 Jan;38(1):89-92.
OBJECTIVE: To investigate the chemical constituents with anti-hypoxia activity from Saussurea involucrata. METHODS: The chemical constituents, isolated and purified by column chromatography from Saussurea involucrata, were identified by several spectroscopic methods. The anti-hypoxic activities of these compounds were examined using the normobaric hypoxic model of mice. RESULTS: Twelve compounds were isolated from petroleum ether extract of Saussurea involucrata and identified as n-octacosane (1), 1-undecanol (2), heptadecan-l-ol(3), heptacosan-1-ol(4), myristicin (5), apiol(6), beta-sitosterol(7), lupeol(8), moslosooflavone (9), Mosloflavone (10), negletein(11), and 5, 6-dihydroxy-7, 8-dimethoxyflavone(12). CONCLUSION: All compounds except 7 and 8 are isolated from this plant for the first time. Compound 1, 5 and 8 - 12 can significantly prolong the survival time of hypoxic mice.
Inhibitory Effects of Norwogonin, Oroxylin A, and Mosloflavone on Enterovirus 71.[Pubmed:27257010]
Biomol Ther (Seoul). 2016 Sep 1;24(5):552-8.
Severe complications associated with EV71 infections are a common cause of neonatal death. Lack of effective therapeutic agents for these infections underlines the importance of research for the development of new antiviral compounds. In the present study, the anti-EV71 activity of norwogonin, oroxylin A, and Mosloflavone from Scutellaria baicalensis Georgi was evaluated using a cytopathic effect (CPE) reduction method, which demonstrated that all three compounds possessed strong anti-EV71 activity and decreased the formation of visible CPEs. Norwogonin, oroxylin A, and Mosloflavone also inhibited virus replication during the initial stage of virus infection, and they inhibited viral VP2 protein expression, thereby inhibiting viral capsid protein synthesis. However, ribavirin has a relatively weaker efficacy compared to the other drugs. Therefore, these findings provide important information that will aid in the utilization of norwogonin, oroxylin A, and Mosloflavone for EV71 treatment.
Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth.[Pubmed:23768253]
Nat Prod Res. 2013;27(23):2227-30.
Herein, we report the isolation and immunomodulatory activity of 11 phytoconstituents, viz. 7 flavonoids, 3 pentacyclic triterpenes and 1 phytosterol of an unexplored plant Actinocarya tibetica Benth. Three flavones, 5-methoxy-6,7-methylenedioxyflavone (6), Mosloflavone (7) and negletein (8), showed promising anti-inflammatory activity via inhibition of TNF-alpha and IL-1beta with IC50 values of 0.22, 0.71, 16.4 muM and 10.8, 7.8, 6.4 muM, respectively. These flavones also showed dose-dependent inhibition of TNF-alpha, IL-1beta and iNOS levels in the supernatant of mouse macrophage cell line J774A. Molecular modelling studies revealed orientation and interactions of flavones 6-8 in the active site of TNF-alpha. These flavones can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases.
A new 2-hydroxyflavanone from Mosla soochouensis.[Pubmed:17260299]
Planta Med. 1999 Dec;65(8):729-31.
A new antifungal and radical scavenging 2-hydroxyflavanone, named mosloflavanone, was isolated from the dichloromethane extract of Mosla soochouensis together with the known Mosloflavone and moslosooflavone. Structures were established by spectroscopic and chemical methods, as well as X-ray crystallography.
