CirsiliolCAS# 34334-69-5 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 34334-69-5 | SDF | Download SDF |
PubChem ID | 160237 | Appearance | Powder |
Formula | C17H14O7 | M.Wt | 330.29 |
Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxychromen-4-one | ||
SMILES | COC1=C(C(=C2C(=C1)OC(=CC2=O)C3=CC(=C(C=C3)O)O)O)OC | ||
Standard InChIKey | IMEYGBIXGJLUIS-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C17H14O7/c1-22-14-7-13-15(16(21)17(14)23-2)11(20)6-12(24-13)8-3-4-9(18)10(19)5-8/h3-7,18-19,21H,1-2H3 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | 1. Cirsiliol shows strong antioxidant activity. 2. Cirsiliol can inhibit TG accumulation in 3T3-L1 preadipocytes, it may have anti-obesity effects. 3. Cirsiliol and rhamnetin can act as promising radiosensitizers that enhance the radiotherapeutic efficacy by inhibiting radiation-induced Notch-1 signaling associated with radioresistance possibly via miR-34a-mediated pathways. |
Targets | NO | NF-kB |
Cirsiliol Dilution Calculator
Cirsiliol Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 3.0276 mL | 15.1382 mL | 30.2764 mL | 60.5528 mL | 75.6911 mL |
5 mM | 0.6055 mL | 3.0276 mL | 6.0553 mL | 12.1106 mL | 15.1382 mL |
10 mM | 0.3028 mL | 1.5138 mL | 3.0276 mL | 6.0553 mL | 7.5691 mL |
50 mM | 0.0606 mL | 0.3028 mL | 0.6055 mL | 1.2111 mL | 1.5138 mL |
100 mM | 0.0303 mL | 0.1514 mL | 0.3028 mL | 0.6055 mL | 0.7569 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Benzyl 2,6-dimethoxybenzoate
Catalog No.:BCN3697
CAS No.:34328-54-6
- OXA (17-33)
Catalog No.:BCC6364
CAS No.:343268-91-7
- TCS PrP Inhibitor 13
Catalog No.:BCC5999
CAS No.:34320-83-7
- Chelerythrine
Catalog No.:BCN5275
CAS No.:34316-15-9
- Boc-Abu-OH.DCHA
Catalog No.:BCC3200
CAS No.:27494-48-0
- 2,16-Kauranediol
Catalog No.:BCN5274
CAS No.:34302-37-9
- Harmine hydrochloride
Catalog No.:BCN2485
CAS No.:343-27-1
- 5,6-Dimethoxy-2-isopropenylbenzofuran
Catalog No.:BCN7195
CAS No.:34293-09-9
- 2,3-Dihydrohinokiflavone
Catalog No.:BCN6680
CAS No.:34292-87-0
- Chikusetsusaponin V methyl ester
Catalog No.:BCN3472
CAS No.:34291-22-0
- SDM25N hydrochloride
Catalog No.:BCC7054
CAS No.:342884-71-3
- Urotensin II-related peptide
Catalog No.:BCC5884
CAS No.:342878-90-4
- NSC697923
Catalog No.:BCC4000
CAS No.:343351-67-7
- NS 3623
Catalog No.:BCC6190
CAS No.:343630-41-1
- Isoapetalic acid
Catalog No.:BCN5276
CAS No.:34366-34-2
- Ginsenoside Ro
Catalog No.:BCN5937
CAS No.:34367-04-9
- CP-673451
Catalog No.:BCC4981
CAS No.:343787-29-1
- Acebutolol HCl
Catalog No.:BCC4322
CAS No.:34381-68-5
- Isovallesiachotamine
Catalog No.:BCN3549
CAS No.:34384-71-9
- N-Demethyl-alpha-obscurine
Catalog No.:BCN7362
CAS No.:34399-44-5
- H-D-Pro-OH
Catalog No.:BCC3023
CAS No.:344-25-2
- Betamipron
Catalog No.:BCC8876
CAS No.:3440-28-6
- Boc-D-Glu-OBzl
Catalog No.:BCC3394
CAS No.:34404-30-3
- H-D-Lys(Z)-OH
Catalog No.:BCC2678
CAS No.:34404-32-5
HPLC-fingerprints and antioxidant constituents of Phyla nodiflora.[Pubmed:25140335]
ScientificWorldJournal. 2014;2014:528653.
Phyla nodiflora is a creeping perennial herb, widely distributed in the most tropical and subtropical regions. It has been used as a folk medicine, herbal beverage, or folk cosmetic. For these usages, the development of a chemical quality control method of this plant is necessary. In the present study, ten compounds, namely, 3,7,4',5'-tetrahydroxy-3'-methoxyflavone (1), nodifloretin (2), 4'-hydroxywogonin (3), onopordin (4), Cirsiliol (5), 5,7,8,4'-tetrahydroxy-3'-methoxyflavone (6), eupafolin (7), hispidulin (8), larycitrin (9), and beta-sitosterol were isolated from the methanolic extract of the aerial part of P. nodiflora (PNM) and their structures were identified by 1D-NMR comparing their spectra with the literature. The antioxidant activities of these compounds were evaluated by free radical scavenging activity and tyrosinase inhibitory effect in cell-free systems. Compounds 4, 5, and 7 showed strong antioxidant activity. To control the quality of P. nodiflora, a simple and reliable method of high-performance liquid chromatography combined with ultraviolet detector (HPLC-UV) was established for both the fingerprint analysis and the quantitative determination of two selected active compounds, onopordin (4) and eupafolin (7). Statistical analysis of the obtained data demonstrated that our method achieved the desired linearity, precision, and accuracy. The results indicated that the developed method can be used as a quality evaluation method for PNM.
Inhibitory effect of chemical constituents from Artemisia scoparia Waldst. et Kit. on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells.[Pubmed:24142543]
J Nat Med. 2014 Apr;68(2):414-20.
We investigated the anti-obesity effect of the aerial part of Artemisia scoparia Waldst. et Kit. (Compositae). An 80 % aqueous EtOH extract of the aerial part inhibited triglyceride (TG) accumulation and the nitric oxide (NO) production activity. A new chromane derivative was isolated from the aerial part of A. scoparia Waldst. et Kit. along with 18 known compounds. The structure of the new chromane, scopariachromane (1), was elucidated by spectroscopic analyses. The inhibitory effects of the compounds on TG accumulation activity were examined. Among these, Cirsiliol (11) inhibited TG accumulation in 3T3-L1 preadipocytes. Jaceosidin (12) inhibited NO production in a murine macrophage-like cell line (RAW 264.7). These results indicate that the 80 % aqueous EtOH extract and compounds isolated from the aerial part of A. scoparia Waldst. et Kit. may improve obesity-related insulin resistance.
Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines.[Pubmed:23902763]
J Biol Chem. 2013 Sep 20;288(38):27343-57.
Radioresistance is a major cause of decreasing the efficiency of radiotherapy for non-small cell lung cancer (NSCLC). To understand the radioresistance mechanisms in NSCLC, we focused on the radiation-induced Notch-1 signaling pathway involved in critical cell fate decisions by modulating cell proliferation. In this study, we investigated the use of Notch-1-regulating flavonoid compounds as novel therapeutic drugs to regulate radiosensitivity in NSCLC cells, NCI-H1299 and NCI-H460, with different levels of radioresistance. Rhamnetin and Cirsiliol were selected as candidate Notch-1-regulating radiosensitizers based on the results of assay screening for activity and pharmacological properties. Treatment with rhamnetin or Cirsiliol reduced the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression. Indeed, rhamnetin and Cirsiliol increased the expression of tumor-suppressive microRNA, miR-34a, in a p53-dependent manner, leading to inhibition of Notch-1 expression. Consequently, reduced Notch-1 expression promoted apoptosis through significant down-regulation of the nuclear factor-kappaB pathway, resulting in a radiosensitizing effect on NSCLC cells. Irradiation-induced epithelial-mesenchymal transition was also notably attenuated in the presence of rhamnetin and Cirsiliol. Moreover, an in vivo xenograft mouse model confirmed the radiosensitizing and epithelial-mesenchymal transition inhibition effects of rhamnetin and Cirsiliol we observed in vitro. In these mice, tumor volume was significantly reduced by combinational treatment with irradiation and rhamnetin or Cirsiliol compared with irradiation alone. Taken together, our findings provided evidence that rhamnetin and Cirsiliol can act as promising radiosensitizers that enhance the radiotherapeutic efficacy by inhibiting radiation-induced Notch-1 signaling associated with radioresistance possibly via miR-34a-mediated pathways.