Harmine hydrochlorideCAS# 343-27-1 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 343-27-1 | SDF | Download SDF |
| PubChem ID | 5359389 | Appearance | Powder |
| Formula | C13H13ClN2O | M.Wt | 248.71 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in DMSO > 10 mM | ||
| Chemical Name | 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride | ||
| SMILES | CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC.Cl | ||
| Standard InChIKey | VNPLYCKZIUTKJM-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C13H12N2O.ClH/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13;/h3-7,15H,1-2H3;1H | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Harmine hydrochloride has potent anti-cancer effects in glioblastoma cells, which is at least partially via inhibition of Akt phosphorylation. |
| Targets | Akt |
| In vitro | Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma.[Pubmed: 23392846]J Neurooncol. 2013 Mar;112(1):39-48.Harmine hydrochloride (Har-hc), a derivative from Harmine which is a natural extractive from plants, has been considered for treatment of kinds of cancers and cerebral diseases. |
Harmine hydrochloride Dilution Calculator
Harmine hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.0207 mL | 20.1037 mL | 40.2075 mL | 80.4149 mL | 100.5187 mL |
| 5 mM | 0.8041 mL | 4.0207 mL | 8.0415 mL | 16.083 mL | 20.1037 mL |
| 10 mM | 0.4021 mL | 2.0104 mL | 4.0207 mL | 8.0415 mL | 10.0519 mL |
| 50 mM | 0.0804 mL | 0.4021 mL | 0.8041 mL | 1.6083 mL | 2.0104 mL |
| 100 mM | 0.0402 mL | 0.201 mL | 0.4021 mL | 0.8041 mL | 1.0052 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma.[Pubmed:23392846]
J Neurooncol. 2013 Mar;112(1):39-48.
Harmine hydrochloride (Har-hc), a derivative from Harmine which is a natural extractive from plants, has been considered for treatment of kinds of cancers and cerebral diseases. In this study, we found that Har-hc clearly decreased cell viability, induced apoptosis and inhibited Akt phosphorylation in glioblastoma cell lines. Moreover, Har-hc had the ability to inhibit self-renewal and promote differentiation of glioblastoma stem like cells (GSLCs) accompanied by inhibition of Akt phosphorylation. Especially, we demonstrated that Har-hc inhibited neurosphere formation of human primary GSLCs. In vivo test also confirmed Har-hc decreased the tumorigenicity of GSLCs. Thus we conclude that Har-hc has potent anti-cancer effects in glioblastoma cells, which is at least partially via inhibition of Akt phosphorylation. Administration of Har-hc may act as a new approach to glioblastoma treatment.
