Home >> Research Area >>Natural Products>>Alkaloids>> Harmine hydrochloride

Harmine hydrochloride

CAS# 343-27-1

Harmine hydrochloride

Catalog No. BCN2485----Order now to get a substantial discount!

Product Name & Size Price Stock
Harmine hydrochloride: 5mg $35 In Stock
Harmine hydrochloride: 10mg Please Inquire In Stock
Harmine hydrochloride: 20mg Please Inquire Please Inquire
Harmine hydrochloride: 50mg Please Inquire Please Inquire
Harmine hydrochloride: 100mg Please Inquire Please Inquire
Harmine hydrochloride: 200mg Please Inquire Please Inquire
Harmine hydrochloride: 500mg Please Inquire Please Inquire
Harmine hydrochloride: 1000mg Please Inquire Please Inquire

Quality Control of Harmine hydrochloride

Number of papers citing our products

Chemical structure

Harmine hydrochloride

3D structure

Chemical Properties of Harmine hydrochloride

Cas No. 343-27-1 SDF Download SDF
PubChem ID 5359389 Appearance Powder
Formula C13H13ClN2O M.Wt 248.71
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in DMSO > 10 mM
Chemical Name 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride
SMILES CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC.Cl
Standard InChIKey VNPLYCKZIUTKJM-UHFFFAOYSA-N
Standard InChI InChI=1S/C13H12N2O.ClH/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13;/h3-7,15H,1-2H3;1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Harmine hydrochloride

The herbs of Peganum harmala L.

Biological Activity of Harmine hydrochloride

DescriptionHarmine hydrochloride has potent anti-cancer effects in glioblastoma cells, which is at least partially via inhibition of Akt phosphorylation.
TargetsAkt
In vitro

Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma.[Pubmed: 23392846]

J Neurooncol. 2013 Mar;112(1):39-48.

Harmine hydrochloride (Har-hc), a derivative from Harmine which is a natural extractive from plants, has been considered for treatment of kinds of cancers and cerebral diseases.
METHODS AND RESULTS:
In this study, we found that Harmine hydrochloride clearly decreased cell viability, induced apoptosis and inhibited Akt phosphorylation in glioblastoma cell lines. Moreover, Harmine hydrochloride had the ability to inhibit self-renewal and promote differentiation of glioblastoma stem like cells (GSLCs) accompanied by inhibition of Akt phosphorylation. Especially, we demonstrated that Harmine hydrochloride inhibited neurosphere formation of human primary GSLCs. In vivo test also confirmed Harmine hydrochloride decreased the tumorigenicity of GSLCs.
CONCLUSIONS:
Thus we conclude that Harmine hydrochloride has potent anti-cancer effects in glioblastoma cells, which is at least partially via inhibition of Akt phosphorylation. Administration of Harmine hydrochloride may act as a new approach to glioblastoma treatment.

Harmine hydrochloride Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Harmine hydrochloride Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Harmine hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.0207 mL 20.1037 mL 40.2075 mL 80.4149 mL 100.5187 mL
5 mM 0.8041 mL 4.0207 mL 8.0415 mL 16.083 mL 20.1037 mL
10 mM 0.4021 mL 2.0104 mL 4.0207 mL 8.0415 mL 10.0519 mL
50 mM 0.0804 mL 0.4021 mL 0.8041 mL 1.6083 mL 2.0104 mL
100 mM 0.0402 mL 0.201 mL 0.4021 mL 0.8041 mL 1.0052 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Harmine hydrochloride

Harmine hydrochloride inhibits Akt phosphorylation and depletes the pool of cancer stem-like cells of glioblastoma.[Pubmed:23392846]

J Neurooncol. 2013 Mar;112(1):39-48.

Harmine hydrochloride (Har-hc), a derivative from Harmine which is a natural extractive from plants, has been considered for treatment of kinds of cancers and cerebral diseases. In this study, we found that Har-hc clearly decreased cell viability, induced apoptosis and inhibited Akt phosphorylation in glioblastoma cell lines. Moreover, Har-hc had the ability to inhibit self-renewal and promote differentiation of glioblastoma stem like cells (GSLCs) accompanied by inhibition of Akt phosphorylation. Especially, we demonstrated that Har-hc inhibited neurosphere formation of human primary GSLCs. In vivo test also confirmed Har-hc decreased the tumorigenicity of GSLCs. Thus we conclude that Har-hc has potent anti-cancer effects in glioblastoma cells, which is at least partially via inhibition of Akt phosphorylation. Administration of Har-hc may act as a new approach to glioblastoma treatment.

Description

Harmine Hydrochloride (Telepathine Hydrochloride) is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM.

Keywords:

Harmine hydrochloride,343-27-1,Natural Products, buy Harmine hydrochloride , Harmine hydrochloride supplier , purchase Harmine hydrochloride , Harmine hydrochloride cost , Harmine hydrochloride manufacturer , order Harmine hydrochloride , high purity Harmine hydrochloride

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: