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TCS PrP Inhibitor 13

Antiprion agent; potently inhibits PrP-res accumulation CAS# 34320-83-7

TCS PrP Inhibitor 13

Catalog No. BCC5999----Order now to get a substantial discount!

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TCS PrP Inhibitor 13: 5mg $92 In Stock
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Chemical structure

TCS PrP Inhibitor 13

3D structure

Chemical Properties of TCS PrP Inhibitor 13

Cas No. 34320-83-7 SDF Download SDF
PubChem ID 2750328 Appearance Powder
Formula C15H11N3O3 M.Wt 281.27
Type of Compound N/A Storage Desiccate at -20°C
Solubility Soluble to 100 mM in DMSO and to 25 mM in ethanol
Chemical Name 5-(4-nitrophenyl)-2-phenyl-4H-pyrazol-3-one
SMILES C1C(=NN(C1=O)C2=CC=CC=C2)C3=CC=C(C=C3)[N+](=O)[O-]
Standard InChIKey FDAVFKZPGQEGDX-UHFFFAOYSA-N
Standard InChI InChI=1S/C15H11N3O3/c19-15-10-14(11-6-8-13(9-7-11)18(20)21)16-17(15)12-4-2-1-3-5-12/h1-9H,10H2
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of TCS PrP Inhibitor 13

DescriptionAntiprion agent. Potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC50 = 3 nM).

TCS PrP Inhibitor 13 Dilution Calculator

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TCS PrP Inhibitor 13 Molarity Calculator

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Preparing Stock Solutions of TCS PrP Inhibitor 13

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5553 mL 17.7765 mL 35.553 mL 71.1061 mL 88.8826 mL
5 mM 0.7111 mL 3.5553 mL 7.1106 mL 14.2212 mL 17.7765 mL
10 mM 0.3555 mL 1.7777 mL 3.5553 mL 7.1106 mL 8.8883 mL
50 mM 0.0711 mL 0.3555 mL 0.7111 mL 1.4221 mL 1.7777 mL
100 mM 0.0356 mL 0.1778 mL 0.3555 mL 0.7111 mL 0.8888 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on TCS PrP Inhibitor 13

New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation.[Pubmed:17850126]

J Med Chem. 2007 Oct 18;50(21):5053-6.

To find effective antiprion compounds, we synthesized and evaluated various pyrazolone derivatives. Seven of 19 compounds showed inhibition of PrP-res accumulation and the remarkably active compound 13 showed an IC50 value of 3 nM in both ScN2a and F3 cell lines. Findings from studies on physicochemical and biochemical properties suggest that the action mechanism of these compounds does not correlate with any antioxidant activities, any of hydroxyl radical scavenging activities, or any SOD-like activities.

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