TCS PrP Inhibitor 13Antiprion agent; potently inhibits PrP-res accumulation CAS# 34320-83-7 |
Related Products
- LKB1 (AAK1 dual inhibitor)
Catalog No.:BCC1705
CAS No.:1093222-27-5
- CX-6258
Catalog No.:BCC1504
CAS No.:1202916-90-2
- CX-6258 hydrochloride hydrate
Catalog No.:BCC1505
CAS No.:1353858-99-7
- PIM-1 Inhibitor 2
Catalog No.:BCC2446
CAS No.:477845-12-8
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 34320-83-7 | SDF | Download SDF |
| PubChem ID | 2750328 | Appearance | Powder |
| Formula | C15H11N3O3 | M.Wt | 281.27 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in DMSO and to 25 mM in ethanol | ||
| Chemical Name | 5-(4-nitrophenyl)-2-phenyl-4H-pyrazol-3-one | ||
| SMILES | C1C(=NN(C1=O)C2=CC=CC=C2)C3=CC=C(C=C3)[N+](=O)[O-] | ||
| Standard InChIKey | FDAVFKZPGQEGDX-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C15H11N3O3/c19-15-10-14(11-6-8-13(9-7-11)18(20)21)16-17(15)12-4-2-1-3-5-12/h1-9H,10H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Antiprion agent. Potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC50 = 3 nM). |
TCS PrP Inhibitor 13 Dilution Calculator
TCS PrP Inhibitor 13 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.5553 mL | 17.7765 mL | 35.553 mL | 71.1061 mL | 88.8826 mL |
| 5 mM | 0.7111 mL | 3.5553 mL | 7.1106 mL | 14.2212 mL | 17.7765 mL |
| 10 mM | 0.3555 mL | 1.7777 mL | 3.5553 mL | 7.1106 mL | 8.8883 mL |
| 50 mM | 0.0711 mL | 0.3555 mL | 0.7111 mL | 1.4221 mL | 1.7777 mL |
| 100 mM | 0.0356 mL | 0.1778 mL | 0.3555 mL | 0.7111 mL | 0.8888 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Featured Products
- Chelerythrine
Catalog No.:BCN5275
CAS No.:34316-15-9
- Boc-Abu-OH.DCHA
Catalog No.:BCC3200
CAS No.:27494-48-0
- 2,16-Kauranediol
Catalog No.:BCN5274
CAS No.:34302-37-9
- Harmine hydrochloride
Catalog No.:BCN2485
CAS No.:343-27-1
- 5,6-Dimethoxy-2-isopropenylbenzofuran
Catalog No.:BCN7195
CAS No.:34293-09-9
- 2,3-Dihydrohinokiflavone
Catalog No.:BCN6680
CAS No.:34292-87-0
- Chikusetsusaponin V methyl ester
Catalog No.:BCN3472
CAS No.:34291-22-0
- SDM25N hydrochloride
Catalog No.:BCC7054
CAS No.:342884-71-3
- Urotensin II-related peptide
Catalog No.:BCC5884
CAS No.:342878-90-4
- Gardneramine
Catalog No.:BCN5273
CAS No.:34274-91-4
- Angiotensin 1/2 (1-9)
Catalog No.:BCC1005
CAS No.:34273-12-6
- Saralasin
Catalog No.:BCC5714
CAS No.:34273-10-4
New Products
- OXA (17-33)
Catalog No.:BCC6364
CAS No.:343268-91-7
- Benzyl 2,6-dimethoxybenzoate
Catalog No.:BCN3697
CAS No.:34328-54-6
- Cirsiliol
Catalog No.:BCN6822
CAS No.:34334-69-5
- NSC697923
Catalog No.:BCC4000
CAS No.:343351-67-7
- NS 3623
Catalog No.:BCC6190
CAS No.:343630-41-1
- Isoapetalic acid
Catalog No.:BCN5276
CAS No.:34366-34-2
- Ginsenoside Ro
Catalog No.:BCN5937
CAS No.:34367-04-9
- CP-673451
Catalog No.:BCC4981
CAS No.:343787-29-1
- Acebutolol HCl
Catalog No.:BCC4322
CAS No.:34381-68-5
- Isovallesiachotamine
Catalog No.:BCN3549
CAS No.:34384-71-9
- N-Demethyl-alpha-obscurine
Catalog No.:BCN7362
CAS No.:34399-44-5
- H-D-Pro-OH
Catalog No.:BCC3023
CAS No.:344-25-2
New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation.[Pubmed:17850126]
J Med Chem. 2007 Oct 18;50(21):5053-6.
To find effective antiprion compounds, we synthesized and evaluated various pyrazolone derivatives. Seven of 19 compounds showed inhibition of PrP-res accumulation and the remarkably active compound 13 showed an IC50 value of 3 nM in both ScN2a and F3 cell lines. Findings from studies on physicochemical and biochemical properties suggest that the action mechanism of these compounds does not correlate with any antioxidant activities, any of hydroxyl radical scavenging activities, or any SOD-like activities.
TCS PrP Inhibitor 13,34320-83-7,Natural Products,Neuronal Metabolism, buy TCS PrP Inhibitor 13 , TCS PrP Inhibitor 13 supplier , purchase TCS PrP Inhibitor 13 , TCS PrP Inhibitor 13 cost , TCS PrP Inhibitor 13 manufacturer , order TCS PrP Inhibitor 13 , high purity TCS PrP Inhibitor 13
