N-Demethyl-alpha-obscurineCAS# 34399-44-5 |
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Cas No. | 34399-44-5 | SDF | Download SDF |
PubChem ID | 46218452 | Appearance | Powder |
Formula | C16H24N2O | M.Wt | 260.38 |
Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
SMILES | CC1CC2CC3=C(CCC(=O)N3)C4(C1)C2CCCN4 | ||
Standard InChIKey | SODGYLLKKFRBQO-AZKPJATDSA-N | ||
Standard InChI | InChI=1S/C16H24N2O/c1-10-7-11-8-14-13(4-5-15(19)18-14)16(9-10)12(11)3-2-6-17-16/h10-12,17H,2-9H2,1H3,(H,18,19)/t10-,11+,12-,16-/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | N-Demethyl-alpha-obscurine is a natural product from Lycopodium japonicum. |
In vitro | Lycopodium alkaloids from Lycopodium japonicum.[Reference: WebLink]Chinese Traditional & Herbal Drugs, 2015, 46(9):1269-1276.
To study the chemical constituents in the whole herb of Lycopodium japonicum. |
Structure Identification | European Journal of Organic Chemistry, 1983, 1983(2):220-225.Synthese desLycopodium-Alkaloidsrac-α-Obscurin durch 1,3-Anellierung eines Enimins.[Reference: WebLink]
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N-Demethyl-alpha-obscurine Dilution Calculator
N-Demethyl-alpha-obscurine Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 3.8405 mL | 19.2027 mL | 38.4054 mL | 76.8108 mL | 96.0135 mL |
5 mM | 0.7681 mL | 3.8405 mL | 7.6811 mL | 15.3622 mL | 19.2027 mL |
10 mM | 0.3841 mL | 1.9203 mL | 3.8405 mL | 7.6811 mL | 9.6014 mL |
50 mM | 0.0768 mL | 0.3841 mL | 0.7681 mL | 1.5362 mL | 1.9203 mL |
100 mM | 0.0384 mL | 0.192 mL | 0.3841 mL | 0.7681 mL | 0.9601 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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Lycopodium alkaloids from Lycopodium japonicum.
Chinese Traditional & Herbal Drugs, 2015, 46(9):1269-1276.
To study the chemical constituents in the whole herb of Lycopodium japonicum. Methods: The constituents were isolated and purified by silica gel and semi-preparative HPLC, and their structures were elucidated by means of physicochemical properties and spectroscopic analysis. All the isolated compounds were evaluated using relevant in vitro anti-inflammatory assay against LPS-induced NO releases. Results: Nineteen compounds were isolated from the whole herb of L. japonicum, and identified as lycoposerramine-M N-oxide (1), acetyllycoposerramine-M (2), lycopodine (3), lycoposerramine-M (4), miyoshianine-C (5), 12-epilycodoline N-oxide (6), gnidioidine (7), lycoposerramine-K (8), lucidioline (9), 4α-hydroxyanhydrolycodoline (10), flabelline (11), hydroxypropyllycodine (12), lycodine (13), des-N-methyl-α-obscurine (N-Demethyl-alpha-obscurine,14), α-obscurine (15), des-N-methyl-β-obscurine (16), lycoflexine (17), lycoflexine N-oxide (18), and fawcettidine (19). Compound 5 and 18 could inhibit the release of nitric oxide (NO) in the RAW264.7 cell line stimulated by lipopolysaccaride. The IC50 values of 5 and 18 are 31.82 and 40.69 μmol/L, respectively. Conclusion: Compound 1 is a new compound, named lycoposerramine-M N-oxide, compounds 2, 6, 11, 12, 16, 18, and 19 are isolated from this plant for the first time. Compounds 5 and 18 exhibit the potent inhibitory activity. ©, 2015, Editorial Office of Chinese Traditional and Herbal Drugs.