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Tirandamycin A

CAS# 34429-70-4

Tirandamycin A

Catalog No. BCN1861----Order now to get a substantial discount!

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Quality Control of Tirandamycin A

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Chemical structure

Tirandamycin A

3D structure

Chemical Properties of Tirandamycin A

Cas No. 34429-70-4 SDF Download SDF
PubChem ID 54706137 Appearance Powder
Formula C22H27NO7 M.Wt 417.46
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (3E)-3-[(2E,4E,6R)-1-hydroxy-4-methyl-6-[(1R,2S,4R,6R,7R,8R)-1,2,7-trimethyl-5-oxo-3,9,10-trioxatricyclo[4.3.1.02,4]decan-8-yl]hepta-2,4-dienylidene]pyrrolidine-2,4-dione
SMILES CC1C2C(=O)C3C(O3)(C(O2)(OC1C(C)C=C(C)C=CC(=C4C(=O)CNC4=O)O)C)C
Standard InChIKey URGUBECARCAPRI-UYXUTHQNSA-N
Standard InChI InChI=1S/C22H27NO7/c1-10(6-7-13(24)15-14(25)9-23-20(15)27)8-11(2)17-12(3)18-16(26)19-21(4,30-19)22(5,28-17)29-18/h6-8,11-12,17-19,24H,9H2,1-5H3,(H,23,27)/b7-6+,10-8+,15-13+/t11-,12-,17-,18-,19+,21+,22-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Tirandamycin A

Description1. Tirandamycin A and echinomycin A have anti-amoebic properties, they inhibit the in vitro growth of a E. histolytica laboratory strain (HM-1:IMSS) and a clinical isolate (Colombia, Col) at 30- to 60- uM concentrations. 2. Tirandamycin A and streptolydigin possess potent antibacterial activity particularly against anaerobes, have been shown to inhibit bacterial RNA polymerase.
TargetsAntifection | DNA/RNA Synthesis

Tirandamycin A Dilution Calculator

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Tirandamycin A Molarity Calculator

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Preparing Stock Solutions of Tirandamycin A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3954 mL 11.9772 mL 23.9544 mL 47.9088 mL 59.886 mL
5 mM 0.4791 mL 2.3954 mL 4.7909 mL 9.5818 mL 11.9772 mL
10 mM 0.2395 mL 1.1977 mL 2.3954 mL 4.7909 mL 5.9886 mL
50 mM 0.0479 mL 0.2395 mL 0.4791 mL 0.9582 mL 1.1977 mL
100 mM 0.024 mL 0.1198 mL 0.2395 mL 0.4791 mL 0.5989 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Tirandamycin A

Antiamoebic properties of the actinomycete metabolites echinomycin A and tirandamycin A.[Pubmed:22763704]

Parasitol Res. 2012 Dec;111(6):2473-7.

Entamoeba histolytica infects 50 million people per year, causing 100,000 deaths worldwide. The primary treatment for amoebiasis is metronidazole. However, increased pathogen resistance combined with the drug's toxic side effects encourages a search for alternative therapeutic agents. Secondary metabolites from marine bacteria are a promising resource for antiprotozoan drug discovery. In this study, extracts from a collection of marine-derived actinomycetes were screened for antiamoebic properties, and the activities of antibiotics echinomycin A and Tirandamycin A are shown. Both antibiotics inhibited the in vitro growth of a E. histolytica laboratory strain (HM-1:IMSS) and a clinical isolate (Colombia, Col) at 30- to 60-muM concentrations. EIC(50) (estimated inhibitory concentration) values were comparable for both antibiotics (44.3-46.3 muM) against the E. histolytica clinical isolate.

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