LathyrolCAS# 34420-19-4 |
Quality Control & MSDS
3D structure
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Number of papers citing our products
| Cas No. | 34420-19-4 | SDF | Download SDF |
| PubChem ID | 5281376 | Appearance | White powder |
| Formula | C20H30O4 | M.Wt | 334.45 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 100 mg/mL (299.00 mM) *"≥" means soluble, but saturation unknown. | ||
| SMILES | CC1CC2(C(C1O)C(C(=C)CCC3C(C3(C)C)C=C(C2=O)C)O)O | ||
| Standard InChIKey | SDBITTRHSROXCY-OKFBFAQVSA-N | ||
| Standard InChI | InChI=1S/C20H30O4/c1-10-6-7-13-14(19(13,4)5)8-11(2)18(23)20(24)9-12(3)17(22)15(20)16(10)21/h8,12-17,21-22,24H,1,6-7,9H2,2-5H3/b11-8+/t12-,13-,14+,15-,16+,17-,20+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Lathyrol diterpenes is a modulator of P-glycoprotein dependent multidrug resistance, and is used for cancer treatment. |
| Targets | P-gp |
| In vitro | Lathyrol diterpenes as modulators of p-glycoprotein dependent multidrug resistance: structure-activity relationship studies on euphorbia factor l3 derivatives.[Pubmed: 25856545]J Med Chem. 2015 May 14;58(9):3720-38.Five series of 37 new acylate and epoxide derivatives (3-39) of Euphorbia factor L3, a Lathyrol diterpene isolated from Euphorbia lathyris, were designed by modifying the hydroxyl moiety of C-3, C-5, or C-15. Chemoreversal effects of the acylates on multidrug resistance (MDR) were evaluated in breast cancer multidrug-resistant MCF-7/ADR cells that overexpress P-glycoprotein (P-gp).
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Lathyrol Dilution Calculator
Lathyrol Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.99 mL | 14.9499 mL | 29.8998 mL | 59.7997 mL | 74.7496 mL |
| 5 mM | 0.598 mL | 2.99 mL | 5.98 mL | 11.9599 mL | 14.9499 mL |
| 10 mM | 0.299 mL | 1.495 mL | 2.99 mL | 5.98 mL | 7.475 mL |
| 50 mM | 0.0598 mL | 0.299 mL | 0.598 mL | 1.196 mL | 1.495 mL |
| 100 mM | 0.0299 mL | 0.1495 mL | 0.299 mL | 0.598 mL | 0.7475 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Lathyrol is a natural product, and is used for cancer treatment.
In Vitro:Lathyrol exhibits reversal effects in MCF-7/ADR breast cancer cell lines in vitro[1].
References:
[1]. Jiao W, et al. Lathyrol diterpenes as modulators of P-glycoprotein dependent multidrug resistance: structure-activity relationship studies on Euphorbia factor L3 derivatives. J Med Chem. 2015 May 14;58(9):3720-38.
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Lathyrol diterpenes as modulators of P-glycoprotein dependent multidrug resistance: structure-activity relationship studies on Euphorbia factor L3 derivatives.[Pubmed:25856545]
J Med Chem. 2015 May 14;58(9):3720-38.
Five series of 37 new acylate and epoxide derivatives (3-39) of Euphorbia factor L3, a Lathyrol diterpene isolated from Euphorbia lathyris, were designed by modifying the hydroxyl moiety of C-3, C-5, or C-15. Chemoreversal effects of the acylates on multidrug resistance (MDR) were evaluated in breast cancer multidrug-resistant MCF-7/ADR cells that overexpress P-glycoprotein (P-gp). Eight derivatives exhibited greater chemoreversal ability than verapamil (VRP) against adriamycin (ADR) resistance. Compounds 19 and 25 exhibited 4.8 and 4.0 times, respectively, more effective reversal ability than VRP against ADR resistance. To determine the key characteristics of Euphorbia factor L3 derivatives that contribute to MDR reversal, we conducted a structure-activity relationship study of these compounds. The simulation studies indicated different possible mechanisms and revealed the important influence of hydrophobic interactions and hydrogen bonds in the flexible cavity of P-gp.
