Lathyrol

CAS# 34420-19-4

Lathyrol

Catalog No. BCN4963----Order now to get a substantial discount!

Product Name & Size Price Stock
Lathyrol: 5mg $35 In Stock
Lathyrol: 10mg Please Inquire In Stock
Lathyrol: 20mg Please Inquire Please Inquire
Lathyrol: 50mg Please Inquire Please Inquire
Lathyrol: 100mg Please Inquire Please Inquire
Lathyrol: 200mg Please Inquire Please Inquire
Lathyrol: 500mg Please Inquire Please Inquire
Lathyrol: 1000mg Please Inquire Please Inquire

Quality Control of Lathyrol

Number of papers citing our products

Chemical structure

Lathyrol

3D structure

Chemical Properties of Lathyrol

Cas No. 34420-19-4 SDF Download SDF
PubChem ID 5281376 Appearance White powder
Formula C20H30O4 M.Wt 334.45
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility DMSO : ≥ 100 mg/mL (299.00 mM)
*"≥" means soluble, but saturation unknown.
SMILES CC1CC2(C(C1O)C(C(=C)CCC3C(C3(C)C)C=C(C2=O)C)O)O
Standard InChIKey SDBITTRHSROXCY-OKFBFAQVSA-N
Standard InChI InChI=1S/C20H30O4/c1-10-6-7-13-14(19(13,4)5)8-11(2)18(23)20(24)9-12(3)17(22)15(20)16(10)21/h8,12-17,21-22,24H,1,6-7,9H2,2-5H3/b11-8+/t12-,13-,14+,15-,16+,17-,20+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Lathyrol

The seeds of Euphorbia lathyris L.

Biological Activity of Lathyrol

DescriptionLathyrol diterpenes is a modulator of P-glycoprotein dependent multidrug resistance, and is used for cancer treatment.
TargetsP-gp
In vitro

Lathyrol diterpenes as modulators of p-glycoprotein dependent multidrug resistance: structure-activity relationship studies on euphorbia factor l3 derivatives.[Pubmed: 25856545]

J Med Chem. 2015 May 14;58(9):3720-38.

Five series of 37 new acylate and epoxide derivatives (3-39) of Euphorbia factor L3, a Lathyrol diterpene isolated from Euphorbia lathyris, were designed by modifying the hydroxyl moiety of C-3, C-5, or C-15. Chemoreversal effects of the acylates on multidrug resistance (MDR) were evaluated in breast cancer multidrug-resistant MCF-7/ADR cells that overexpress P-glycoprotein (P-gp).
METHODS AND RESULTS:
Eight derivatives exhibited greater chemoreversal ability than verapamil (VRP) against adriamycin (ADR) resistance. Compounds 19 and 25 exhibited 4.8 and 4.0 times, respectively, more effective reversal ability than VRP against ADR resistance. To determine the key characteristics of Euphorbia factor L3 derivatives that contribute to MDR reversal, we conducted a structure-activity relationship study of these compounds.
CONCLUSIONS:
The simulation studies indicated different possible mechanisms and revealed the important influence of hydrophobic interactions and hydrogen bonds in the flexible cavity of P-gp.

Lathyrol Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Lathyrol Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Lathyrol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.99 mL 14.9499 mL 29.8998 mL 59.7997 mL 74.7496 mL
5 mM 0.598 mL 2.99 mL 5.98 mL 11.9599 mL 14.9499 mL
10 mM 0.299 mL 1.495 mL 2.99 mL 5.98 mL 7.475 mL
50 mM 0.0598 mL 0.299 mL 0.598 mL 1.196 mL 1.495 mL
100 mM 0.0299 mL 0.1495 mL 0.299 mL 0.598 mL 0.7475 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University

Background on Lathyrol

Lathyrol is a natural product, and is used for cancer treatment.

In Vitro:Lathyrol exhibits reversal effects in MCF-7/ADR breast cancer cell lines in vitro[1].

References:
[1]. Jiao W, et al. Lathyrol diterpenes as modulators of P-glycoprotein dependent multidrug resistance: structure-activity relationship studies on Euphorbia factor L3 derivatives. J Med Chem. 2015 May 14;58(9):3720-38.

Featured Products
New Products
 

References on Lathyrol

Lathyrol diterpenes as modulators of P-glycoprotein dependent multidrug resistance: structure-activity relationship studies on Euphorbia factor L3 derivatives.[Pubmed:25856545]

J Med Chem. 2015 May 14;58(9):3720-38.

Five series of 37 new acylate and epoxide derivatives (3-39) of Euphorbia factor L3, a Lathyrol diterpene isolated from Euphorbia lathyris, were designed by modifying the hydroxyl moiety of C-3, C-5, or C-15. Chemoreversal effects of the acylates on multidrug resistance (MDR) were evaluated in breast cancer multidrug-resistant MCF-7/ADR cells that overexpress P-glycoprotein (P-gp). Eight derivatives exhibited greater chemoreversal ability than verapamil (VRP) against adriamycin (ADR) resistance. Compounds 19 and 25 exhibited 4.8 and 4.0 times, respectively, more effective reversal ability than VRP against ADR resistance. To determine the key characteristics of Euphorbia factor L3 derivatives that contribute to MDR reversal, we conducted a structure-activity relationship study of these compounds. The simulation studies indicated different possible mechanisms and revealed the important influence of hydrophobic interactions and hydrogen bonds in the flexible cavity of P-gp.

Description

Lathyrol is a natural product, and is used for cancer treatment.

Keywords:

Lathyrol,34420-19-4,Natural Products, buy Lathyrol , Lathyrol supplier , purchase Lathyrol , Lathyrol cost , Lathyrol manufacturer , order Lathyrol , high purity Lathyrol

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: