AmycomycinCAS# 344362-08-9 |
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| Cas No. | 344362-08-9 | SDF | Download SDF |
| PubChem ID | 54708635 | Appearance | Powder |
| Formula | C65H115NO18 | M.Wt | 1198.62 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3E,5Z)-1-methyl-5-(2-methylpropylidene)-3-[(2E,20E,24E)-1,5,7,11,13,17,19,26,27,29,31,35,37,41,43-pentadecahydroxy-2,10,12,18,20,22,24,32,40,42,44-undecamethyl-23-oxopentatetraconta-2,20,24-trienylidene]pyrrolidine-2,4-dione | ||
| SMILES | CC(C)C=C1C(=O)C(=C(C(=CCC(CC(CCC(C)C(C(C)C(CCCC(C(C)C(C(=CC(C)C(=O)C(=CC(C(CC(CC(C(C)CCC(CC(CCC(C)C(C(C)C(C(C)C)O)O)O)O)O)O)O)O)C)C)O)O)O)O)O)O)C)O)C(=O)N1C | ||
| Standard InChIKey | VNFAKMBHDHVYLZ-HSTNYJNZSA-N | ||
| Standard InChI | InChI=1S/C65H115NO18/c1-34(2)27-51-64(83)57(65(84)66(51)15)63(82)39(8)22-26-49(70)31-47(68)24-20-37(6)60(79)43(12)52(72)17-16-18-53(73)44(13)62(81)41(10)28-40(9)59(78)42(11)29-55(75)56(76)33-50(71)32-54(74)36(5)19-23-46(67)30-48(69)25-21-38(7)61(80)45(14)58(77)35(3)4/h22,27-29,34-38,40,43-50,52-56,58,60-62,67-77,79-82H,16-21,23-26,30-33H2,1-15H3/b39-22+,41-28+,42-29+,51-27-,63-57+ | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The Amycolatopsis sp.
| Description | 1. Amycomycin is active against gram-positive bacteria , it is useful as an antibiotic. |
| Targets | Antifection |
Amycomycin Dilution Calculator
Amycomycin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 0.8343 mL | 4.1715 mL | 8.3429 mL | 16.6859 mL | 20.8573 mL |
| 5 mM | 0.1669 mL | 0.8343 mL | 1.6686 mL | 3.3372 mL | 4.1715 mL |
| 10 mM | 0.0834 mL | 0.4171 mL | 0.8343 mL | 1.6686 mL | 2.0857 mL |
| 50 mM | 0.0167 mL | 0.0834 mL | 0.1669 mL | 0.3337 mL | 0.4171 mL |
| 100 mM | 0.0083 mL | 0.0417 mL | 0.0834 mL | 0.1669 mL | 0.2086 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Angucyclines from an insect-derived actinobacterium Amycolatopsis sp. HCa1 and their cytotoxic activity.[Pubmed:23131338]
Bioorg Med Chem Lett. 2012 Dec 15;22(24):7490-3.
One new angucyclinone derivative, Amycomycin A (1), and one new angucycline, Amycomycin B (2), along with 5 known compounds (3-7), were isolated from an actinobacterium Amycolatopsis sp. HCa1 associated with the grasshopper, Oxya chinensis. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 1-7 were tested in vitro for their cytotoxic effects on five cell lines including human gastric adenocarcinoma cell line (BGC823), human hepatocarcinoma cell line (HepG2), human melanoma cell line (A375), human oral squamous carcinoma cell line (KB), and ghost cell line (Ghost-R5X4). Cell viability assays showed that compound 7 was active in four cell lines with IC(50) values less than 18.0 muM except in KB showing no activity up to 100 muM.
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