GardneramineCAS# 34274-91-4 |
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| Cas No. | 34274-91-4 | SDF | Download SDF |
| PubChem ID | 6441560 | Appearance | Powder |
| Formula | C23H28N2O5 | M.Wt | 412.5 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | COCC=C1CN2C3CC1C4C2CC35C6=C(C(=CC(=C6OC)OC)OC)N=C5OC4 | ||
| Standard InChIKey | RIMDDIPKIZTBHU-KPDHXFAYSA-N | ||
| Standard InChI | InChI=1S/C23H28N2O5/c1-26-6-5-12-10-25-15-9-23-18(25)7-13(12)14(15)11-30-22(23)24-20-16(27-2)8-17(28-3)21(29-4)19(20)23/h5,8,13-15,18H,6-7,9-11H2,1-4H3/b12-5+/t13-,14+,15+,18?,23?/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Gardneria multiflora Makino
| Description | 1. Gardneramine and hirsutine show a local anesthetic action, they also can inhibit the ganglionic transmission of the dog urinary bladder and that the blockade of the nicotinic receptor plays a main role. 2. Gardneramine has a mild central depressive effect. |
Gardneramine Dilution Calculator
Gardneramine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.4242 mL | 12.1212 mL | 24.2424 mL | 48.4848 mL | 60.6061 mL |
| 5 mM | 0.4848 mL | 2.4242 mL | 4.8485 mL | 9.697 mL | 12.1212 mL |
| 10 mM | 0.2424 mL | 1.2121 mL | 2.4242 mL | 4.8485 mL | 6.0606 mL |
| 50 mM | 0.0485 mL | 0.2424 mL | 0.4848 mL | 0.9697 mL | 1.2121 mL |
| 100 mM | 0.0242 mL | 0.1212 mL | 0.2424 mL | 0.4848 mL | 0.6061 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Site of the ganglion blocking action of gardneramine and hirsutine in the dog urinary bladder in situ preparation.[Pubmed:6193306]
Jpn J Pharmacol. 1983 Apr;33(2):463-71.
The ganglion blocking site of Gardneramine (GA) and hirsutine (HS) was studied in the dog urinary bladder in an in situ preparation. GA and HS selectively inhibited the DMPP-induced contraction without having an antagonistic effect on the McN-A-343-induced and acetylcholine-induced contraction. In addition, since GA and HS showed a local anesthetic action weaker than that of procaine, the effect of procaine was studied on the same preparation. Procaine inhibited the McN-A-343-induced contraction, and it slightly inhibited the DMPP-induced and acetylcholine-induced contraction. From these findings, it is concluded that GA and HS inhibited the ganglionic transmission of the dog urinary bladder and that the blockade of the nicotinic receptor played a main role.
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