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BCN1441 |
14-Deoxy-11,12-didehydroandrographolide
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14-Deoxy-11,12-didehydroandrographolide has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions, it causes negative chronotropic action and antagonised isoproterenol-induced positive chronotropic actions in a non-competitive and dose-dependent manner. 14-Deoxy-11,12-didehydroandrographolide can effectively ameliorate astrocytic pro-inflammatory reactions and prevent PC12 cell death with different efficacies, it may be candidates for treatment of spinal-cord injury and neurodegeneration. |
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BCN2270 |
Gomisin J
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Gomisin J is a good substrate of cytochrome P450 3A4(CYP3A4),
it has vasodilatory, anti-inflammatory, anti-diabetes, anti-oxidant, and anti-cancer effects, it also has preventive effects on angiotensin II-induced hypertension via an increased nitric oxide bioavailability. Gomisin J has potential benefits in treating nonalcoholic fatty liver disease, it can suppress lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecule. Halogenated gomisin J is a potent inhibitor of the cytopathic effects of human immunodeficiency virus type 1 (HIV-1) on MT-4 human T cells (50% effective dose, 0.1 to 0.5 microM). |
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BCN2280 |
Saponarin
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1. Saponarin, which isolated from Gypsophila trichotoma Wend, shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
2. Saponarin has antioxidant activity against cocaine-induced oxidative stress and hepatotoxicity.
3. Saponarin exerts anti-inflammatory effects in LPS-induced RAW 264.7 macrophages via inhibition of NF-κB, ERK and p38 signaling.
4. Saponarin shows hypoglycemic activity in the range of 20-80 mg/kg compared to 100-200 mg/kg for acarbose as reported.
5. Saponarin is characterized as α-glucosidase inhibitor present in Tinospora cordifolia, it also has hypoglycemic activity.
6. Saponarin exerts slight antihypertensive activity in non-diabetic spontaneously hypertensive rats (SHR), however, such effect is not observed in streptozotocin-induced diabetic SHR (SHR-D), indicates that diabetes and hypertension in combination are more difficult to be modulated by saponarin. |
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BCN2322 |
Corilagin
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Corilagin has antitumour, anti-inflammatory, antioxidant, antifibrotics, antiviral, antibacterial, hepatoprotective, antiatherogenic, and antihypertensive activities. Corilagin reduces the cytotoxicity induced by EV71 or CA16 on Vero cells with and IC50 value of 5.6 and 32.33 μg/mL, respectively; it shows the potential to protect against HSV-1-induced encephalitis, and the beneficial effects may be mediated by inhibiting TLR2 signaling pathways. Corilagin attenuates bleomycin-induced epithelial injury and fibrosis via inactivation of oxidative stress, proinflammatory cytokine release and NF-κB and TGF-β1 signaling; it suppresses the activity of beta-lactamase to some extent. |
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BCN2347 |
Allicin
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1. Allicin exerts a unique bactericidal effect on biofilm-embedded bacteria.
2. Allicin can treat cancer via alleviating liver injury by as an adjuvant to Tamoxifen .
3. Allicin has protective effects on H9c2 cells, could inhibit intracellular ROS production instead of scavenging extracellular H(2)O(2) or free radicals.
4. Allicin could significantly inhibit vascular smooth muscle cells' proliferation and migration induced by insulin, which may be related to the inhibition of the activation of ERK signal path.
5. Allicin may inhibit the proliferation and induce the apoptosis of MGC‑803 human gastric carcinoma cells, and this may partially be achieved through the enhanced expression of p38 and cleaved caspase 3.
6. Allicin is beneficial in reducing blood cholesterol, triglycerides levels and systolic blood pressure in hypercholesterolemic rats, it may beneficially affect two risk factors for atherosclerosis–hyperlipidemia and hypertension.
7. Allicin exhibits antioxidant activities as protective compounds against free radical damage.
8. Allicin can strongly inhibit cysteine proteinases and cytopathic effects of Entamoeba histolytica.
9. Allicin is an anti-inflammatory agent , it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells and suggest that allicin may have the potential to attenuate intestinal inflammation. |
