Products with Antihypertensive bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5080 | Strictosamide |
| 1. Strictosamide may have important effects on inflammation and inflammatory pain. 2. Strictosamide is slightly toxic to Charles River mouse (LD(50)=723.17 mg/kg), producing CNS depression and kidney toxicity. 3. Strictosamide has nonsignificant in vitro and in vivo effect on kidney Na(+),K(+)-ATPase activity but produced an in vivo increase of Na(+),K(+)-ATPase activity of brain. 4. Strictosamide possesses antibacterial and antiviral activities. | |
| BCN5325 | Serpentinine |
| 1. Serpentinine may have antihypertensive effect. | |
| BCN5346 | Protoveratrine A |
| 1. Protoveratrine A enhances the release of acetylcholine from the nerve terminals during the resting period and at low frequency of stimulation. 2. Protoveratrine A seems to involve at least in part an inhibition of dopaminergic neuron activity. 3. Protoveratrine A has depolarizing effects on the rat diaphram. 4. Protoveratrine A has some effects on cardiovascular and respiratory systems in rats in reducing the blood pressure and heart rate,prolonging the QTc interval,decreasing the respiratory rate and increasing the respiratory width. 5. Protoveratrine A can increase K + uptake from frog skeletal muscle and cause this tissue to release more calcium (Ca ++ ). 6. Protoveratrine A has anti-hypertensive action. | |
| BCN5365 | Syrosingopine |
| 1. Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor. 2. Syrosingopine can sensitize cancer cells to metformin and its more potent derivative phenformin far below the individual toxic threshold of each compound, thus, combining syrosingopine and codrugs is a promising therapeutic strategy for clinical application for the treatment of cancer. 3. Syrosingopine has hypotensive properties. | |
| BCN5366 | Resibufogenin |
| Resibufogenin is a cytotoxic steroid isolated from the Chinese drug ChanSu, which exhibits the anti-proliferative effect against cancer cells through the degradation of cyclin D1 caused by the activation of GSK-3β. Resibufogenin can inhibit rectifier potassium current ( I K ) and transient potassium current ( I A ), it has pathological effects on central nervous system. Resibufogenin corrects hypertension in a rat model of human preeclampsia, it not only prevents the advent of hypertension and proteinuria, but also the development of intrauterine growth restriction. | |
