Products with Estrogenic effect bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4720 | Kazinol U |
| 1. Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. 2. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms. | |
| BCN4739 | Barpisoflavone A |
| 1. Barpisoflavone A possesses moderate estrogen partial agonistic activities and moderate antioxidant activities. | |
| BCN4816 | Phaseollin |
| 1. Phaseollin and neorautenol may be responsible for the anticarcinogenic actions of the plant extract, may lead to new pharmacons to be used in cancer therapy. 2. 9-Aminoacridine and other DNA intercalators function as inducers of Phaseollin and phenylalanine ammonia lyase synthesis by reacting with the DNA template. 3. The red kidney bean phytoalexins kievitone and phaseollin possess both estrogenic and antiestrogenic activities. | |
| BCN5196 | Secoisolariciresinol |
| 1. Secoisolariciresinol and matairesinol are enterolignan precursors. 2. Secoisolariciresinol has antioxidant activity. 3. Secoisolariciresinol and isotaxiresinol prevent d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha. 4. Secoisolariciresinol has estrogen-like activity, it can significantly suppress triglyceride (TG) accumulation in 3T3-L1 adipocytes. 5. (-)-Secoisolariciresinol exerts a suppressive effect on the gain of body weight of mice fed a high-fat diet by inducing gene expression of adiponectin, resulting in the altered expression of various genes related to the synthesis and β-oxidation of fatty acids. | |
| BCN5232 | Isobavachin |
| Isobavachin can stimulate osteoblasts proliferation and differentiation; it also can facilitate mouse embryonic stem cells differentiating into neuronal cells, the mechanism involved protein prenylation and, subsequently, phos-ERK activation and the phos-p38 off pathway. Isobavachin possesses estrogen-like activity in MCF-7/BOS cells, it can significantly stimulate the proliferation of MCF-7/BOS cells in a dose-dependent manner. Isobavachin has cytotoxic effects on H4IIE hepatoma and metabolically poorly active C6 glioma cells. | |
