Products with Estrogenic effect bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1224 | Biochanin A |
| Biochanin A, an O-methylated natural isoflavonoid classified as phytoestrogen, is a naturally occurring fatty acid amide hydrolase (FAAH) inhibitor, which inhibits FAAH with IC50s of 1.8, 1.4 and 2.4 μM for mouse, rat, and human FAAH, respectively. Biochanin A has hypoglycemic, antilipemic,anti-tumorigenesis, anti-oxidation, and anti-inflammatory properties, it also has neuroprotective effects in cerebral ischemia/reperfusion by inhibiting inflammatory response and the inactivation of p38 signaling pathway. Biochanin A could inhibit Methicillin-resistant Staphylococcus aureus efflux system through reducing pathogen' s expression of nor A and norA protein. | |
| BCN1433 | Soyasapogenol A |
| 1. Soyasapogenol A and soyasapogenol B concentrated extracts show a greater ability to inhibit proliferation of cultured Hep-G2 when compared to a total soyasaponin extract that did not contain any soyasapogenols. 2. Soyasapogenol A directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-α, which consequently resulted in the prevention of liver damage in the concanavalin A-induced hepatitis model. 3. Soyasapogenol A shows estrogenic activities. | |
| BCN1634 | Tamoxifen |
| 1. Tamoxifen acts as an estrogen agonist by preventing the skeletal alterations that result from ovarian hormone deficiency. 2. Tamoxifen is currently the first-line therapy for treatment of hormone-dependent breast cancer. | |
| BCN2235 | Estriol |
| Estriol (E3), an endogenous estrogen predominantly produced during human pregnancy, is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells. E3 can blunt the postprandial glycemic surge in rats through modulating the level of intestinal glucose transporters. E3 exerts a mitogenic effect on T-47D and MCF-7 cells at concentrations of 10(-9)M (288 pg/ml) and higher. | |
| BCN2236 | Estriol 3-sulfate |
| 1. Estriol 3-sulfate acts through the hydrolyzed E3, E3-17-S is inactive because it is not hydrolyzed, so Estriol 3-sulfate can play an important role in the biological responses of this mammary cancer cell line. | |
