Products with Estrogenic effect bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3256 | Licoflavone C |
| 1. Licoflavone C has cytotoxic effect . 2. Licoflavone C has antioxidative effect. 3. Licoflavone C has protective effect toward the chromosome damage induced by DAU or MMC in cultured human peripheral lymphocytes. 4. Licoflavone C exhibits a dose-dependent antagonistic activity at concentrations up to 10−4 M, but stimulates β-galactosidase expression at higher concentrations resulting in a U-shaped-like dose-response curve. | |
| BCN3949 | Coumestrol |
| 1. Coumestrol suppresses the accumulation of HIF-1α via suppression of SPHK1 pathway in hypoxic PC-3 cells. 2. Coumestrol is a novel inducer of mitochondrial biogenesis through the activation of Sirt1. 3. Coumestrol can function by inhibiting oncogenic disease, at least in part, through CKII inhibition-mediated cellular senescence. 4. Coumestrol treatment is effective in preventing neuronal loss in all times of administration as well as able to rescue the Na+, K+ -ATPase activity, suggesting its potential benefits for either prevention or therapeutics use against cerebral ischemia in males. | |
| BCN4136 | Acteoside |
| Acteoside is a lipase inhibitor, has neuroprotective, anti-obesity,anti-inflammatory, antioxidant, anticancer, cytotoxic,antihypertensive, analgesic, and antimetastatic activities. Acteoside can promote nerve growth factor and tropomycin receptor kinase A expression, inhibit arachidonic acid release and prostaglandin E2 production induced by 0.5 microM melittin. Acteoside can protect the cells from X‑ray induced damage through enhancing the scavenging activity of ROS, decreasing the Bax/Bcl-2 ratio and downregulating the activity of procaspase-3, as well as modulating the mitogen‑activated protein kinase signaling pathways. | |
| BCN4512 | Isoliquiritigenin |
| Isoliquiritigenin has hepatoprotective, chemopreventive, antitumor, vasorelaxant, anti-platelet, anti-allergic, antiviral, antioxidant and anti-inflammatory effects, it can induce growth inhibition and apoptosis through downregulating AA metabolic network and the deactivation of PI3K/Akt in human breast cancer. Isoliquiritigenin also has the ability to protect cells from AA+iron-induced H2O2 production and mitochondrial dysfunction, which is mediated with GSK3β phosphorylation downstream of AMPK. | |
| BCN4592 | Broussonin A |
| 1. Broussonins A and B, new phytoalexins from diseased paper mulberry. 2. Broussonin A and nyasol suppress lipopolysaccharide (LPS)-stimulated inducible nitric oxide synthase (iNOS) expression at the transcriptional level through modulating NF-κB and down-regulation of the Akt and ERK signaling pathways. 3. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. 4. Broussonin A can significantly inhibit adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay. | |
