Products with Hepatotoxicity bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4218 | Diosbulbin D |
| 1. Diosbulbin D shows direct toxic effect on hepatocytes, the mechanism could be associated with oxidative stress. | |
| BCN4306 | (-)-Usnic acid |
| Usnic acid has antitumoral, acaricidal, larvicidal, antiviral, antibiotic, antipyretic, analgesic,gastroprotective, antioxidative and anti-inflammatory activities. Use of reconstituted bovine type-I collagen-based films containing usnic acid can improve burn healing process in rats. Usnic acid perturbs various interrelated signaling pathways and that autophagy induction is a defensive mechanism against usnic acid-induced cytotoxicity; it disturbs calcium homeostasis, induces ER stress, and that Usnic acid-induced cellular damage occurs at least partially via activation of the Ca(2+) channel of SOCE. | |
| BCN4333 | 9-Oxo-10,11-dehydroageraphorone |
| 1. 9-Oxo-10,11-dehydroageraphorone has acaricidal activity. 2. 9-Oxo-10,11-dehydroageraphorone induces hepatotoxicity and cholestasis in rats. 3. 9-Oxo-10,11-dehydroageraphorone effectively inhibits the proliferation of HeLa cells by arresting the cell cycle transition from S to G2/M phase. | |
| BCN4605 | Precocene II |
| 1. Precocene II is a botanically derived chemical that inhibits the production of juvenile hormone (JH) in insects. 2. Precocene II is highly toxic to adult female Rhodnius and treatment of newly emerged females prevented oogenesis. 3. Precocene II , an insect growth regulator that is structurally related to several naturally occurring carcinogenic and non-carcinogenic alkenylbenzenes, is genotoxic and produces hepatic centrolobular necrosis in rats. | |
| BCN4871 | Bavachinin |
| Bavachinin is a novel natural pan-PPAR agonist , it shows stronger activities with PPAR-γ than with PPAR-α and PPAR-β/δ (EC50 = 0.74 μmol/l, 4.00 μmol/l and 8.07 μmol/l in 293T cells, respectively). Bavachinin possesses anti-asthma, anti-angiogenic , anti-inflammatory, antipyretic and analgesic properties, it also exhibits glucose-lowering properties without inducing weight gain and hepatotoxicity. | |
