Products with Hepatotoxicity bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2133 | Riddelline |
| 1. Riddelline is a potent genotoxic agent in vitro and induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver. | |
| BCN2145 | Trichodesmine |
| 1. Trichodesmine has greater lethality and neurotoxicity than monocrotaline, because of the two structural characteristics: (a) steric hindrance at position 14 of dehydroTrichodesmine results in greater resistance to hydrolysis, allowing more to be released from the liver and to be delivered to the brain; (b) the larger isopropyl substituent at position 14 of dehydroTrichodesmine renders the molecule more lipophilic, leading to greater penetration of the brain. | |
| BCN2176 | Dronedarone |
| Dronedarone is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV). | |
| BCN2306 | Methysticin |
| 1. Methysticin and yangonin show in vitro hepatotoxicity on human hepatocytes (HepG2) . 2. Methysticin and 7,8-dihydroMethysticin contribute to CYP1A1 induction. 3. Methysticin is a potent NF-kappaB inhibitor in kava with minimum toxicity. 4. Methysticin possesses anticonvulsant and neuroprotective properties, possibly by interfering with frequency potentiation. | |
| BCN4145 | Deoxycalyciphylline B |
| 1. Deoxycalyciphylline B exhibits hepatic toxicity. 2. Deoxycalyciphylline B and Methyl homosecodaphniphyllate show different inhibitory effects on thephenoloxidase (PO) of Spodoptera exigua (Hbner) and the inhibitor concentrations leading to 50% (IC50) activity lost are estimated to be 2.439 mmol·L-1 for deoxycalyciphyllineB and 0.879mmol·L-1 for methyl homosecodaphniphyllate,respectively. | |
