Products with Hepatotoxicity bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2056 | Adonifoline |
| 1. Adonifoline is a hepatotoxic pyrrolizidine alkaloid. | |
| BCN2063 | Isoline |
| 1. Isoline decreases the cellular GSH and the ratio of GSH and oxidizes glutathione in a time- and concentration-dependent manner in L-02 cells. 2. Isoline can induce different oxidative injury in various important mouse organs, and of which liver is the most sensitive organ. 3. An in silico drug target searching program INVDOCK identified 2 potential protein targets of Isoline. 4. l-Buthionine-(S, R)-sulfoximine (BSO) and mercaptosuccinic acid (MA), inhibitors of GCL and GPx, both augmented Isoline-induced cytotoxicity in cultured mice hepatocytes. | |
| BCN2067 | Clivorine |
| 1. Clivorine has anti-proliferative function in L-02 cells may be due to its inducing cell apoptosis with independent of p53 protein. 2. Clivorine itself has direct toxicity on HEK293 cells, and phosphorylated JNK may play some role in counteracting the toxicity of Clivorine on HEK293 cells. 3. Clivorine induces hepatotoxicity and acute liver injury, which can be protected by quercetin, trolox and epidermal growth factor via inhibiting apoptotic cell death and ameliorating oxidative stress injury. | |
| BCN2082 | Fulvine |
| 1. Fulvine is a hepatotoxic pyrrolizidine alkaloid. 2. An aqueous solution of Fulvine can produce an acute pancreatopathy with interstitial oedema and secondary hypoxic dystrophy of the acinar cells, when administered at doses of 10 and 20 mg/kg body weight. | |
| BCN2090 | Ligularine |
| 1. Ligularine and clivorine are two hepatotoxic otonecine-type pyrrolizidine alkaloids. | |
