Diosbulbin DCAS# 66756-57-8 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 66756-57-8 | SDF | Download SDF |
| PubChem ID | 100021 | Appearance | Powder |
| Formula | C19H20O6 | M.Wt | 344.4 |
| Type of Compound | Diterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC12CC(OC(=O)C1CC(=O)C3C2CC4CC3C(=O)O4)C5=COC=C5 | ||
| Standard InChIKey | FJCWYLRNGKSUCH-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C19H20O6/c1-19-7-15(9-2-3-23-8-9)25-18(22)13(19)6-14(20)16-11-4-10(5-12(16)19)24-17(11)21/h2-3,8,10-13,15-16H,4-7H2,1H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Diosbulbin D shows direct toxic effect on hepatocytes, the mechanism could be associated with oxidative stress. |
| Targets | ROS |
Diosbulbin D Dilution Calculator
Diosbulbin D Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9036 mL | 14.518 mL | 29.036 mL | 58.072 mL | 72.59 mL |
| 5 mM | 0.5807 mL | 2.9036 mL | 5.8072 mL | 11.6144 mL | 14.518 mL |
| 10 mM | 0.2904 mL | 1.4518 mL | 2.9036 mL | 5.8072 mL | 7.259 mL |
| 50 mM | 0.0581 mL | 0.2904 mL | 0.5807 mL | 1.1614 mL | 1.4518 mL |
| 100 mM | 0.029 mL | 0.1452 mL | 0.2904 mL | 0.5807 mL | 0.7259 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- NSC 109555 ditosylate
Catalog No.:BCC7540
CAS No.:66748-43-4
- MeBIO
Catalog No.:BCC3898
CAS No.:667463-95-8
- BIO-acetoxime
Catalog No.:BCC6076
CAS No.:667463-85-6
- GSK-3 Inhibitor IX (BIO)
Catalog No.:BCC4510
CAS No.:667463-62-9
- PG 931
Catalog No.:BCC6363
CAS No.:667430-81-1
- 5-Hydroxy-7-acetoxyflavone
Catalog No.:BCN4217
CAS No.:6674-40-4
- DBU
Catalog No.:BCC2840
CAS No.:6674-22-2
- 3-Nitro-L-tyrosine ethyl ester hydrochloride
Catalog No.:BCN1384
CAS No.:66737-54-0
- E-64
Catalog No.:BCC1222
CAS No.:66701-25-5
- 8-Bromo-7-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H,7H)-dione
Catalog No.:BCC8786
CAS No.:666816-98-4
- Polygalacin D
Catalog No.:BCN3861
CAS No.:66663-91-0
- Platycodin D2
Catalog No.:BCN3847
CAS No.:66663-90-9
- 6,8-Diprenylorobol
Catalog No.:BCN4602
CAS No.:66777-70-6
- Esculin Sesquihydrate
Catalog No.:BCC8324
CAS No.:66778-17-4
- Platycodin A
Catalog No.:BCN7997
CAS No.:66779-34-8
- Impurity B of Calcitriol
Catalog No.:BCC1645
CAS No.:66791-71-7
- Syringaresinol-di-O-glucoside
Catalog No.:BCN2600
CAS No.:66791-77-3
- (+/-)-Forbesione
Catalog No.:BCN6423
CAS No.:667914-50-3
- Hernandezine
Catalog No.:BCN7793
CAS No.:6681-13-6
- Jatrorrhizine chloride
Catalog No.:BCN4956
CAS No.:6681-15-8
- Magnoflorine chloride
Catalog No.:BCN2405
CAS No.:6681-18-1
- Linagliptin (BI-1356)
Catalog No.:BCC2110
CAS No.:668270-12-0
- LDN 57444
Catalog No.:BCC2087
CAS No.:668467-91-2
- Halobetasol Propionate
Catalog No.:BCC4664
CAS No.:66852-54-8
Sensitive bromine-based screening of potential toxic furanoids in Dioscorea bulbifera L.[Pubmed:28477535]
J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jul 1;1057:1-14.
Numerous furanoids have been reported to be toxic, and many of them were found in herbal medicines. Toxicities of furanoids are suggested to result from the generation of cis-enedials via biotransformation. The detection of the electrophilic metabolic intermediates is a challenge. Earlier, we developed a selective approach to screen potential toxic furanoids, through which we found two major furanoids, diosbulbin B and 8-epidiosbulbin E acetate, in Dioscorea bulbifera L., a known furanoid-containing and hepatotoxic herbal medicine. In the present study, we improved the approach to analyze furanoids in D. bulbifera L., which allowed us to detect additional six potential furanoids, including diosbulbin A, Diosbulbin D, diosbulbin E, diosbulbin F, diosbulbin M, and Diosbulbin D glycoside. The achievements of this study enhanced the sensitivity to screen potential toxic furanoids through elevating S/N values by approximately 3 times. This will facilitate the understanding of mechanisms of toxic actions of D. bulbifera L. and other furanoid-containing toxic herbal medicines.
[Chemical constituents from tubers of Dioscorea bulbifera].[Pubmed:19873780]
Zhongguo Zhong Yao Za Zhi. 2009 Jul;34(13):1679-82.
OBJECTIVE: To study the chemical constituents in the tubers of Dioscorea bulbifera. METHOD: Compounds were isolated and purified with silica gel, ODS and Sephadex LH-20 column chromatography, their structures were determined by using spectroscopic methods including MS and NMR. RESULT: Fourteen compounds were isolated and identified as stigmasterol (1), mono-arachidin (2), 1,7-bis-(4-hydroxyphenyl)-1E,4E,6E-heptatrien-3-one (3), behenic acid (4), demethyl batatasin IV (5), 2,3'-di-hydroxy-4',5'-dimethoxybibenzyl (6), diosbulbin B (7), Diosbulbin D (8), docosyl ferulate (9), 7-bis-(4-hydroxyphenyl) -4E, 6E-heptadien-3-one (10), 5,3,4-trihydroxy-3,7-dimethoxyflavone (11), tristin(12), protocatechuic acid (13), adenosine (14). CONCLUSION: Compounds 24, 6, 9, 10, 12, 14 were isolated from the genus Dioscorea for the first time.
