Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2683 | Chikusetsusaponin IV |
| 1. Chikusetsusaponin IV might relieve cutaneous symptoms caused by excessive apoptotic cell death in the skin through the Fas/FasL pathway. | |
| BCN2726 | Dihydrorotenone |
| 1. Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome. 2. Dihydrorotenone induces human plasma cell apoptosis by provoking endoplasmic reticulum stress and induces cell death by activating the p38 but not the JNK signaling pathway. | |
| BCN2738 | Tracheloside |
| Tracheloside significantly decreases the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an IC(50) value of 0.31 microg/ml, a level of inhibition comparable to that of tamoxifen (IC(50) = 0.43 microg/ml). | |
| BCN2744 | Sarcosine |
| Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist, it preconditioning induces ischemic tolerance against global cerebral ischemia and this neuroprotective state is associated with changes in glycine transport and reduction of NR2B-containing NMDAR expression.Sarcosine modulates endothelial cell function relevant to angiogenesis through modulation of PI3K/Akt/mTOR pathway. | |
| BCN2767 | Beta,beta-Dimethylacrylalkannin |
| Beta,beta-Dimethylacrylalkannin has radical scavenging activity, it exhibits inhibitory activities on PTP1B with IC50 values of 0.36±0.08 umol·L-1, it may be a new type of leading compounds for the treatment of diabetes. Beta,beta-Dimethylacrylalkannin has great potential as topo I inhibitors compared to other compounds and CPT-11, with 2-3uM inhibition value. Beta,beta-Dimethylacrylalkannin can be potential therapeutics against tumor cell growth because of its unique DNA damaging abilities additional to enzyme inhibition similar to those of doxorubicin. | |
