Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2526 | Garcinone D |
| 1. Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml. 2. Garcinone D inhibits p65 activation with IC50 values of 3.2 microM. 3. Garcinone D exhibits dose-dependent enzyme-based microsomal aromatase inhibitory activity. | |
| BCN2563 | 4-Methylumbelliferone |
| 4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM, which has antitumoral and antimetastatic effects. 4-Methylumbelliferone may inhibit the phosphorylation of HAS2 by PKC through the stimulation of O-GlcNAcylation; it also similarly ameliorates hypertriglyceridemia and hyperglycemia partly by modulating hepatic lipid metabolism and the antioxidant defense system along with increasing adiponectin levels. | |
| BCN2568 | Mevastatin |
| Mevastatin inhibits HMGCR (HMG-CoA reductase) which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin inhibits the differentiation of TAO derived orbital preadipocytes by blocking PPAR-gamma mRNA expression. Mevastatin induces cell growth inhibition and apoptosis in SACC cells, it triggers the phosphorylation of the EGFR and inhibits the c-Jun N-terminal kinase pathway. | |
| BCN2586 | Plumbagin |
| Plumbagin, a potential natural FOXM1 inhibitor, has anticancer, and anti-fibrotic activies, it inactivates the NF-κB/TLR-4 pathway that is associated with inflammatory reactions, thereby mitigating liver fibrosis. Plumbagin offers significant protective role against DEX-induced cellular damage via regulating oxidative stress, apoptosis, and osteogenic markers. | |
| BCN2604 | Topotecan hydrochloride |
| Topotecan hydrochloride, a topoisomerase I inhibitor, capable of inhibiting tumoral growth in animal models of retinoblastoma. Topotecan hydrochloride liposomes loaded CS/β-GP hydrogel could become a potential formulation for improving the antitumor efficacy of Topotecan hydrochloride. | |
