Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN2276 | Calebassine |
| 1. Calebassine is a competitive neuromuscular blocking agent. 2. Calebassine is a Mdm2/MdmX inhibitor. | |
| BCN2282 | Demethylzeylasteral |
| Demethylzeylasteral exhibits strong inhibition towards UDP-glucuronosyltransferase (UGT) 1A6 and 2B7, and the inhibition kinetic parameters (Ki) are calculated to be 0.6 uM and 17.3 uM for UGT1A6 and UGT2B7, respectively. Demethylzeylasteral has antimicrobial, strong immunosuppressive, and antifertility activities; it concentration-dependently and in a partially reversible manner can inhibit the Ca(2+) current in spermatogenic cells with an IC(50) of 8.8 microg/ml, and it also can inhibit significantly the sperm acrosome reaction initiated by progesterone. | |
| BCN2284 | Ikarisoside F |
| 1. Ikarisoside F and epimedin A can bind to AdoHcy hydrolase, inhibit the activity of AdoHcy hydrolase, thus regulating the cellular biomethylation as well as reducing cellular Hcy level. | |
| BCN2286 | Coptisine sulfate |
| Coptisine sulfate can competitively inhibit CYP2D6(*)1 and CYP2D6(*)10, its Ki values for CYP2D6(*)1 and CYP2D6(*)10 are very close, suggesting that genotype-dependent herb-drug inhibition is similar between the two variants. | |
| BCN2290 | (-)-Asarinin |
| Asarinin, a mammalian lignan precursor, has immunosuppression activity in vitro. Asarinin can decrease peripheral blood concentration of interleukin (IL)-12 and inhibit the expression of Toll-like receptor 4 (TLR4) and chemokine (C-X-C motif) receptor 3 (CXCR3), which means asarinin may have a role on TLR4 pathway and produced prolongation of allograft heart survival. | |
