Products with Precursors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5165 | Baccatin III |
| Baccatin III, which is the precursor for the semisynthesis of paclitaxel,exerts anti-tumor immunomodulatory activity in very low doses (0.05-0.5mg/kg),it reduces tumor progression by inhibiting the accumulation and suppressive function of MDSCs. Baccatin III also exerts immunomodulatory activities in vivo as well as in vitro on the MHC-restricted antigen presentation. | |
| BCN5196 | Secoisolariciresinol |
| 1. Secoisolariciresinol and matairesinol are enterolignan precursors. 2. Secoisolariciresinol has antioxidant activity. 3. Secoisolariciresinol and isotaxiresinol prevent d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha. 4. Secoisolariciresinol has estrogen-like activity, it can significantly suppress triglyceride (TG) accumulation in 3T3-L1 adipocytes. 5. (-)-Secoisolariciresinol exerts a suppressive effect on the gain of body weight of mice fed a high-fat diet by inducing gene expression of adiponectin, resulting in the altered expression of various genes related to the synthesis and β-oxidation of fatty acids. | |
| BCN5237 | Hesperetin 7-O-glucoside |
| 1. Hesperetin 7-O-glucoside can reduce blood pressure in healthy volunteers. 2. Hesperetin 7-O-glucoside shows inhibition of human HMG-CoA reductase, it also exhibits effective inhibition of the growth of Helicobacter pylori. 3. Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. | |
| BCN5251 | 10-Deacetylbaccatin III |
| 10-Deacetylbacccatin III is an antineoplastic agent and an anti-cancer intermediate, it can selectively inhibit the growth of L. donovani intracellular amastigotes within J774 murine macrophages in vitro at nanomolar concentrations with an IC50 value of 70 nM. The 10-Deacetylbaccatin III-treated promastigotes were slightly arrested in the G2/M phase whereas taxol-treated cells were blocked in the G2/M phase. | |
| BCN5456 | Yatein |
| 1. Yatein is a lignan precursor of podophyllotoxin, a key agent in anticancer drugs. 2. Yatein can significantly suppress HSV-1 multiplication in HeLa cells without apparent cytotoxicity. | |
