Products with Toxicity bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4650 | Paclitaxel |
| Paclitaxel is a potent anticancer medication which can promote microtubule (MT) assembly, inhibits MT depolymerization, and changes MT dynamics required for mitosis and cell proliferation. Paclitaxel can induce ototoxicity in rats. | |
| BCN4734 | Annonacin |
| 1. Annonacin is mitochondrial complex I inhibitor, reported to be more toxic than rotenone to mesencephalic neurons; can cause significant cell death in various cancer cell lines.. 2. Annonacin induces growth arrest and apoptosis in ERα-related pathways in MCF-7 cells, attenuates MCF-7 xenograft tumor growth while inhibiting ERα, cyclin D1 and Bcl-2 protein expressions in nude mice. 3. Annonacin-induced ATP depletion causes the retrograde transport of mitochondria to the cell soma and induces changes in the intracellular distribution of tau in a way that shares characteristics with some neurodegenerative diseases. | |
| BCN4853 | Enniatin B1 |
| 1. Enniatin B1 has intestinal toxicity. 2. Enniatins A, A(1), B, B(1) have antifungal effects. 3. Enniatins A1, B and B1 induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. | |
| BCN4879 | Diosbulbin B |
| Diosbulbin B has potential anti-tumor effects which may be related to influencing the immune system for the first time, it also exhibits potential hepatotoxicity. | |
| BCN4881 | Xanthotoxol |
| Xanthotoxol shows strong pharmacological activities as anti-inflammatory, antioxidant, cytotoxic, dose-graded sedative, 5-HT antagonistic, and neuroprotective effects.Xanthotoxol also has calcium antagonistic effects, it blocks not only the voltage dependent calcium channel, but also the receptor operated calcium channel in the isolated guinea pig atria. | |
