Products with Toxicity bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4983 | Crotaline |
| Crotaline venoms produce various toxic effects, although these are most commonly treated with specific antivenoms. Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid (PA) that causes a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension, and cor pulmonale. | |
| BCN5159 | alpha-Hederin |
| alpha-Hederin possesses several biological properties such as antispasmodic, moliscicidic, anthelmithic and inhibiting cell proliferation, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential in Leishmania. alpha-Hederin has anti-oxidant activity and acute anti-inflammatory activity in carrageenan-induced rat paw edema. alpha-Hederin can increase isoprenaline-induced relaxation indirectly, probably by inhibiting heterologous desensitization induced by high concentrations of muscarinic ligands like. | |
| BCN5275 | Chelerythrine |
| Chelerythrine is a well-known protein kinase C inhibitor, can inhibit telomerase activity, it also can block the human P2X 7 receptor. Chelerythrine has antimanic, potential antiproliferative and antitumor effects, it has significant cytotoxic effect, independent of p53 and androgen status, on human prostate cancer cell lines. | |
| BCN5285 | Palmatine |
| Palmatine shows significant antidepressant-like, anti-hyperlipidemia, hepatoprotective, and antioxidant effects, it inhibited MAO-A, I(K) and I(CRAC) activity, and activated the AhR-CYP1A pathway. Palmatine shows the strong toxic action on T. thermophila BF5 growth, it is toxic to insects and vertebrates and inhibited the multiplication of bacteria, fungi and viruses, it is active at the alpha 2-receptor ( IC50 of 956 nM). | |
| BCN5383 | Atractyloside A |
| 1. Atractyloside is a toxic compound from wedelia glauca. 2. Atractyloside acts as inhibitor of oxidative phosphorylation by a specific interference with energy-transfer reactions, the effect of atractyloside is due to inhibition of the ADP utilizing process in the coupling system. 3. Atractyloside, has been proposed for the antibiotic oligomycin, is an inhibitor of the energy-transfer reactions in animal mitochondria; it inhibits the phosphate uptake and the respiratory stimulation induced by P1-acceptor, but it does not interfere with the so-called resting respiration. | |
