Products with Toxicity bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1550 | 3-O-(2'E ,4'Z-decadienoyl)-20-O-acetylingenol |
| 1. 3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol, one toxic terpenoid from raw Gansui. 2. 3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol has strong cytotoxicity against human normal cell lines L-O2 and GES-1 with dose-dependent relationships . 3. 20-O-acetyl-[3-O-(2'E,4'Z)-decadienoyl]-ingenol and 3-O-(2'E,4'Z)-decadienoylingenol show the same antinematodal activity against the nematode, Bursaphelenchus xylophilus, at a minimum effective dose (MED) of 5 microg/cotton ball. 4. 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol induces the cytotoxicity of intestinal epithelial cells of rats (IEC-6 cells) depends on induction of cell apoptosis via mitochondrial pathway and cell cycle arrest. 5. 3-O-(2'E,4'Z-decadienoyl)-20-O-acetylingenol, kansuinine B and kansuinine A can markedly promote SPL proliferation and NO production by PMphi at concentrations from 0.78 to 12.50 microg/mL, hence the they are believed to be important proinflammatory components of the roots of E. kansui. | |
| BCN1709 | Sambutoxin |
| 1. Sambutoxin, a new mycotoxin produced by toxic Fusarium isolates obtained from rotted potato tubers, it can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines, and, finally, death when rats were fed diets supplemented with 0.05 and 0.1% sambutoxin. 2. Sambutoxin inhibits rabbit platelet aggregation, which may be party due to the decrease of ATP release. 3. Sambutoxin has in vitro cytotoxicity against various human and murine tumor cells and values of sambutoxin ranged from 46.2 to 1,425.6 ng/ml. | |
| BCN1715 | beta-Amyrin acetate |
| 1. beta-Amyrin acetate and β-amyrin palmitate as antidyslipidemic agents, they show significant HMG-CoA-reductase inhibition. 2. beta-Amyrin acetate and honokiol exhibit sEH inhibitory activity. 3. beta-Amyrin acetate has a high antioxidant potential with an IC50 value of 158.2ug/mL, and has cytotoxicity , it could be a viable source of antioxidant and cytotoxic agents in cancer chemotherapy in the near future. 4. beta-Amyrin acetate has anti-inflammatory activity,with ID50 values in the range of 0.15-0.75 micromol/ear. 5. beta-Amyrin acetate exhibits weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line. | |
| BCN1811 | Pahutoxin |
| 1. Pahutoxin is a natural fish-killing (ichthyotoxic) agent derived from the defensive secretions of trunkfish. 2. Pahutoxin is a haemolytic agent. | |
| BCN1816 | Tetramethylammonium |
| 1. Tetramethylammonium ion has limited toxicity of dermal exposure, but fatal effects can be introduced by pre-treatment with hydroxide ion. | |
