Atractyloside ACAS# 126054-77-1 |
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| Cas No. | 126054-77-1 | SDF | Download SDF |
| PubChem ID | 71307451 | Appearance | Powder |
| Formula | C21H36O10 | M.Wt | 448.5 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | DMSO : ≥ 30 mg/mL (66.89 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | (3S,3aR,5R,8R,8aS)-3,8-dihydroxy-8-(hydroxymethyl)-3-methyl-5-[2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropan-2-yl]-3a,4,5,6,7,8a-hexahydro-1H-azulen-2-one | ||
| SMILES | CC1(C2CC(CCC(C2CC1=O)(CO)O)C(C)(C)OC3C(C(C(C(O3)CO)O)O)O)O | ||
| Standard InChIKey | QNBLVYVBWDIWDM-BSLJOXIBSA-N | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Atractylodes lancea (Thunb.) DC.
| Description | 1. Atractyloside is a toxic compound from wedelia glauca. 2. Atractyloside acts as inhibitor of oxidative phosphorylation by a specific interference with energy-transfer reactions, the effect of atractyloside is due to inhibition of the ADP utilizing process in the coupling system. 3. Atractyloside, has been proposed for the antibiotic oligomycin, is an inhibitor of the energy-transfer reactions in animal mitochondria; it inhibits the phosphate uptake and the respiratory stimulation induced by P1-acceptor, but it does not interfere with the so-called resting respiration. |
Atractyloside A Dilution Calculator
Atractyloside A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.2297 mL | 11.1483 mL | 22.2965 mL | 44.5931 mL | 55.7414 mL |
| 5 mM | 0.4459 mL | 2.2297 mL | 4.4593 mL | 8.9186 mL | 11.1483 mL |
| 10 mM | 0.223 mL | 1.1148 mL | 2.2297 mL | 4.4593 mL | 5.5741 mL |
| 50 mM | 0.0446 mL | 0.223 mL | 0.4459 mL | 0.8919 mL | 1.1148 mL |
| 100 mM | 0.0223 mL | 0.1115 mL | 0.223 mL | 0.4459 mL | 0.5574 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Atractyloside A(126054-77-1) is a natural TCM reference compound.
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Binding characterization of the targeting drug AIMPILA to AFP receptors in human tumor xenografts.[Pubmed:28990489]
Tumour Biol. 2017 Oct;39(10):1010428317734815.
The main objective of this study was the characterization of preclinical tumor models based on their expression of alpha-fetoprotein receptor (RECAF) for targeting cancer cells with a new non-covalent complex (AIMPILA) containing alpha-fetoprotein as the carrier and Atractyloside As an apoptosis-inducing agent. For that purpose, we measured the amount of RECAF in the homogenates of the grafted tumors T47D and SW620 and in HepG2 cell extracts. We also determined the alpha-fetoprotein binding specificity of the targeting drug AIMPILA using a solid-phase chemiluminescent assay with AIMPILA-Acrdidinium. We found that RECAF is practically absent from healthy mice tissues (100 Units/mg) where in malignant cells, the amount of alpha-fetoprotein receptors follows this order: T47D (9152 Units/mg) > HepG2 (4865 Units/mg) > SW620 (2839 Units/mg). This agrees with our findings regarding AIMPILA-induced tumor growth inhibition (T47D (T/C = 22%) > HepG2 (T/C = 51%) > SW620 (T/C = 70%), where T/C is the ratio of tumor volume in treated vs control animals). Our results demonstrate that the therapeutic response to the targeting drug AIMPILA strongly depends on the RECAF expression by human tumors and confirms the choice of the tumor models used for an AIMPILA preclinical study.
Atractyloside A is a natural TCM reference compound.
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