3-Oxo-21alpha-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactoneCAS# 1260173-73-6 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1260173-73-6 | SDF | Download SDF |
| PubChem ID | 102263760 | Appearance | Powder |
| Formula | C27H40O4 | M.Wt | 428.61 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (4S,5R)-5-methoxy-4-[(5R,9R,10R,13S,14S,17S)-4,4,10,13,14-pentamethyl-3-oxo-1,2,5,6,9,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]oxolan-2-one | ||
| SMILES | CC1(C2CC=C3C(C2(CCC1=O)C)CCC4(C3(CCC4C5CC(=O)OC5OC)C)C)C | ||
| Standard InChIKey | XFNPHQKEXAQLKO-WNURWBIPSA-N | ||
| Standard InChI | InChI=1S/C27H40O4/c1-24(2)20-8-7-19-18(25(20,3)12-11-21(24)28)10-14-26(4)17(9-13-27(19,26)5)16-15-22(29)31-23(16)30-6/h7,16-18,20,23H,8-15H2,1-6H3/t16-,17-,18-,20-,23+,25+,26-,27+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The stem barks of Aphanamixis grandifolia.
| Description | 1. 3-Oxo-21alpha-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone may show cytotoxic activities against five tumor cell lines (MCF-7, HeLa, HepG2, SGC-7901 and BGC-823). |
3-Oxo-21alpha-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone Dilution Calculator
3-Oxo-21alpha-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.3331 mL | 11.6656 mL | 23.3312 mL | 46.6625 mL | 58.3281 mL |
| 5 mM | 0.4666 mL | 2.3331 mL | 4.6662 mL | 9.3325 mL | 11.6656 mL |
| 10 mM | 0.2333 mL | 1.1666 mL | 2.3331 mL | 4.6662 mL | 5.8328 mL |
| 50 mM | 0.0467 mL | 0.2333 mL | 0.4666 mL | 0.9332 mL | 1.1666 mL |
| 100 mM | 0.0233 mL | 0.1167 mL | 0.2333 mL | 0.4666 mL | 0.5833 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Cytotoxic tirucallane C26 triterpenoids from the stem barks of Aphanamixis grandifolia.[Pubmed:20851441]
Phytochemistry. 2010 Dec;71(17-18):2199-204.
Five tirucallane type C(26) triterpenoids, accompanied by two known compounds, 3alpha-hydroxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone and 3-oxo-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone, were isolated from the stem barks of Aphanamixis grandifolia. Their structures were established mainly by means of a combination of 1D and 2D NMR spectroscopic and mass spectrometry techniques as 3alpha-hydroxyl-21alpha-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone , 3alpha-hydroxy-21beta-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone, 3-Oxo-21alpha-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone, 3-oxo-21beta-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone, and 3-oxo-21alpha-ethoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone. All isolates were in vitro evaluated for their cytotoxic activities against five tumor cell lines (MCF-7, HeLa, HepG2, SGC-7901 and BGC-823).
3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone is a cytotoxic tirucallane C26 triterpenoid isolated from the stem barks of Aphanamixis grandifolia.
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