Polygalic acid

CAS# 1260-04-4

Polygalic acid

Catalog No. BCN3172----Order now to get a substantial discount!

Product Name & Size Price Stock
Polygalic acid: 5mg $23 In Stock
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Quality Control of Polygalic acid

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Chemical structure

Polygalic acid

3D structure

Chemical Properties of Polygalic acid

Cas No. 1260-04-4 SDF Download SDF
PubChem ID 12442765 Appearance White powder
Formula C29H44O6 M.Wt 488.7
Type of Compound Triterpenoids Storage Desiccate at -20°C
Synonyms Senegenic acid
Solubility DMSO : ≥ 250 mg/mL (511.60 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name (2S,3R,4S,4aR,6aR,8aS,12aS,14aR,14bR)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4a,5,6,7,8,9,10,12,12a,13,14,14a-tetradecahydro-1H-picene-4,8a-dicarboxylic acid
SMILES CC1(CCC2(CCC3=C(C2C1)CCC4C3(CCC5C4(CC(C(C5(C)C(=O)O)O)O)C)C)C(=O)O)C
Standard InChIKey VZRKWGPIZJDNHC-LUNVCWBOSA-N
Standard InChI InChI=1S/C29H44O6/c1-25(2)12-13-29(24(34)35)11-8-17-16(18(29)14-25)6-7-20-26(17,3)10-9-21-27(20,4)15-19(30)22(31)28(21,5)23(32)33/h18-22,30-31H,6-15H2,1-5H3,(H,32,33)(H,34,35)/t18-,19-,20-,21+,22-,26-,27+,28-,29+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Polygalic acid

The roots of Polygala tenuifolia Willd

Biological Activity of Polygalic acid

DescriptionPolygalic acid, a triterpenoid saponin, shows expectorant, emetic and stimulant effects.
In vivo

In vivo metabolism study of polygalic acid in rat using HPLC-ESI-MSn.[Pubmed: 21618563 ]

Biomed Chromatogr. 2012 Feb;26(2):220-4.

A very simple and direct method has been established for the determination of Polygalic acid and its metabolites in rat urine based on HPLC coupled with electrospray ionization multi-stage tandem mass spectrometry (HPLC-ESI-MS(n)).
METHODS AND RESULTS:
The rats were administered a single dose (100 mg/kg) of Polygalic acid by oral gavage. The urine samples were collected and purified through a C(18) solid-phase extraction cartridge, and then these pretreated samples were injected into a reversed-phase C(18) column with a gradient elution program, whereas acetonitrile-0.5% aqueous formic acid was used as mobile phase and detected by an on-line MS/MS system. As a result, the parent drug and its four metabolites were identified and characterized in rat urine for the first time by comparing their changes in molecular mass (ΔM), retention times and full-scan MS(n) spectra with those of the parent drug. A possible metabolic pathway of Polygalic acid was investigated and proposed.
CONCLUSIONS:
More importantly, the results demonstrated that the newly developed method (HPLC-ESI-MS(n)) was sensitive, simple and suitable for the determination of Polygalic acid and its metabolites in biological samples.

Polygalic acid Dilution Calculator

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Polygalic acid Molarity Calculator

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Preparing Stock Solutions of Polygalic acid

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0462 mL 10.2312 mL 20.4625 mL 40.9249 mL 51.1561 mL
5 mM 0.4092 mL 2.0462 mL 4.0925 mL 8.185 mL 10.2312 mL
10 mM 0.2046 mL 1.0231 mL 2.0462 mL 4.0925 mL 5.1156 mL
50 mM 0.0409 mL 0.2046 mL 0.4092 mL 0.8185 mL 1.0231 mL
100 mM 0.0205 mL 0.1023 mL 0.2046 mL 0.4092 mL 0.5116 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Polygalic acid

In vivo metabolism study of polygalic acid in rat using HPLC-ESI-MSn.[Pubmed:21618563]

Biomed Chromatogr. 2012 Feb;26(2):220-4.

A very simple and direct method has been established for the determination of Polygalic acid and its metabolites in rat urine based on HPLC coupled with electrospray ionization multi-stage tandem mass spectrometry (HPLC-ESI-MS(n)). The rats were administered a single dose (100 mg/kg) of Polygalic acid by oral gavage. The urine samples were collected and purified through a C(18) solid-phase extraction cartridge, and then these pretreated samples were injected into a reversed-phase C(18) column with a gradient elution program, whereas acetonitrile-0.5% aqueous formic acid was used as mobile phase and detected by an on-line MS/MS system. As a result, the parent drug and its four metabolites were identified and characterized in rat urine for the first time by comparing their changes in molecular mass (DeltaM), retention times and full-scan MS(n) spectra with those of the parent drug. A possible metabolic pathway of Polygalic acid was investigated and proposed. More importantly, the results demonstrated that the newly developed method (HPLC-ESI-MS(n)) was sensitive, simple and suitable for the determination of Polygalic acid and its metabolites in biological samples.

Description

Polygalic acid, a triterpenoid saponin, is considered one of the major active constituents of Polygala tenuifolia.

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