Polygalic acidCAS# 1260-04-4 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 1260-04-4 | SDF | Download SDF |
| PubChem ID | 12442765 | Appearance | White powder |
| Formula | C29H44O6 | M.Wt | 488.7 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Synonyms | Senegenic acid | ||
| Solubility | DMSO : ≥ 250 mg/mL (511.60 mM) *"≥" means soluble, but saturation unknown. | ||
| Chemical Name | (2S,3R,4S,4aR,6aR,8aS,12aS,14aR,14bR)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4a,5,6,7,8,9,10,12,12a,13,14,14a-tetradecahydro-1H-picene-4,8a-dicarboxylic acid | ||
| SMILES | CC1(CCC2(CCC3=C(C2C1)CCC4C3(CCC5C4(CC(C(C5(C)C(=O)O)O)O)C)C)C(=O)O)C | ||
| Standard InChIKey | VZRKWGPIZJDNHC-LUNVCWBOSA-N | ||
| Standard InChI | InChI=1S/C29H44O6/c1-25(2)12-13-29(24(34)35)11-8-17-16(18(29)14-25)6-7-20-26(17,3)10-9-21-27(20,4)15-19(30)22(31)28(21,5)23(32)33/h18-22,30-31H,6-15H2,1-5H3,(H,32,33)(H,34,35)/t18-,19-,20-,21+,22-,26-,27+,28-,29+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Polygalic acid, a triterpenoid saponin, shows expectorant, emetic and stimulant effects. |
| In vivo | In vivo metabolism study of polygalic acid in rat using HPLC-ESI-MSn.[Pubmed: 21618563 ]Biomed Chromatogr. 2012 Feb;26(2):220-4.A very simple and direct method has been established for the determination of Polygalic acid and its metabolites in rat urine based on HPLC coupled with electrospray ionization multi-stage tandem mass spectrometry (HPLC-ESI-MS(n)). |
Polygalic acid Dilution Calculator
Polygalic acid Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.0462 mL | 10.2312 mL | 20.4625 mL | 40.9249 mL | 51.1561 mL |
| 5 mM | 0.4092 mL | 2.0462 mL | 4.0925 mL | 8.185 mL | 10.2312 mL |
| 10 mM | 0.2046 mL | 1.0231 mL | 2.0462 mL | 4.0925 mL | 5.1156 mL |
| 50 mM | 0.0409 mL | 0.2046 mL | 0.4092 mL | 0.8185 mL | 1.0231 mL |
| 100 mM | 0.0205 mL | 0.1023 mL | 0.2046 mL | 0.4092 mL | 0.5116 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Oxethazaine
Catalog No.:BCC3832
CAS No.:126-27-2
- Sarsasapogenin
Catalog No.:BCN1269
CAS No.:126-19-2
- Solasodine
Catalog No.:BCN2346
CAS No.:126-17-0
- Griseofulvin
Catalog No.:BCC5327
CAS No.:126-07-8
- 10-O-Ethylcannabitriol
Catalog No.:BCN7312
CAS No.:1259515-25-7
- SCH 23390 hydrochloride
Catalog No.:BCC6849
CAS No.:125941-87-9
- VU 0155041 sodium salt
Catalog No.:BCC7642
CAS No.:1259372-69-4
- JP 1302 dihydrochloride
Catalog No.:BCC7449
CAS No.:1259314-65-2
- SAMS Peptide
Catalog No.:BCC5745
CAS No.:125911-68-4
- 24-Methylenecycloartanol acetate
Catalog No.:BCN6137
CAS No.:1259-94-5
- (+)-Glaucarubinone
Catalog No.:BCN7956
CAS No.:1259-86-5
- LY2940680
Catalog No.:BCC3935
CAS No.:1258861-20-9
- Phlegmanol C
Catalog No.:BCN6138
CAS No.:1260-05-5
- Carminic acid
Catalog No.:BCN6541
CAS No.:1260-17-9
- 28-Deoxonimbolide
Catalog No.:BCN4717
CAS No.:126005-94-5
- TAK-438
Catalog No.:BCC1182
CAS No.:1260141-27-2
- 3-Oxo-21alpha-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone
Catalog No.:BCN7028
CAS No.:1260173-73-6
- TCS 21311
Catalog No.:BCC2443
CAS No.:1260181-14-3
- Birinapant (TL32711)
Catalog No.:BCC2250
CAS No.:1260251-31-7
- 3-O-beta-Allopyranosyl-(1->4)-beta-oleandropyranosyl-11-O-isobutyryl-12-O-acetyltenacigenin B
Catalog No.:BCN6765
CAS No.:1260252-18-3
- GSK 525768A
Catalog No.:BCC1603
CAS No.:1260530-25-3
- Atractyloside A
Catalog No.:BCN5383
CAS No.:126054-77-1
- 6-O-Methylcerevisterol
Catalog No.:BCN6139
CAS No.:126060-09-1
- I-BET-762
Catalog No.:BCC4474
CAS No.:1260907-17-2
In vivo metabolism study of polygalic acid in rat using HPLC-ESI-MSn.[Pubmed:21618563]
Biomed Chromatogr. 2012 Feb;26(2):220-4.
A very simple and direct method has been established for the determination of Polygalic acid and its metabolites in rat urine based on HPLC coupled with electrospray ionization multi-stage tandem mass spectrometry (HPLC-ESI-MS(n)). The rats were administered a single dose (100 mg/kg) of Polygalic acid by oral gavage. The urine samples were collected and purified through a C(18) solid-phase extraction cartridge, and then these pretreated samples were injected into a reversed-phase C(18) column with a gradient elution program, whereas acetonitrile-0.5% aqueous formic acid was used as mobile phase and detected by an on-line MS/MS system. As a result, the parent drug and its four metabolites were identified and characterized in rat urine for the first time by comparing their changes in molecular mass (DeltaM), retention times and full-scan MS(n) spectra with those of the parent drug. A possible metabolic pathway of Polygalic acid was investigated and proposed. More importantly, the results demonstrated that the newly developed method (HPLC-ESI-MS(n)) was sensitive, simple and suitable for the determination of Polygalic acid and its metabolites in biological samples.
