Rubiyunnanin CCAS# 1261030-04-9 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 1261030-04-9 | SDF | Download SDF |
| PubChem ID | 50915211 | Appearance | Powder |
| Formula | C43H52N6O11 | M.Wt | 828.91 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| SMILES | CC1C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)N(C2CC3=CC=C(C=C3)OC4=C(C=CC(=C4)CC(C(=O)N1)N(C2=O)C)O)C)C)CC5=CC=C(C=C5)OC)C)CCC(=O)OC | ||
| Standard InChIKey | LGZQUONMJBBEDW-DETZFJOKSA-N | ||
| Standard InChI | InChI=1S/C43H52N6O11/c1-24-38(52)46-31(17-19-37(51)59-7)42(56)47(3)32(20-26-8-13-29(58-6)14-9-26)40(54)45-25(2)41(55)49(5)34-21-27-10-15-30(16-11-27)60-36-23-28(12-18-35(36)50)22-33(39(53)44-24)48(4)43(34)57/h8-16,18,23-25,31-34,50H,17,19-22H2,1-7H3,(H,44,53)(H,45,54)(H,46,52)/t24-,25+,31+,32+,33+,34+/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Rubiyunnanin C exhibits cytotoxic activities against a panel of eleven cancer cell lines and exerts inhibitory activities against nitric oxide (NO) production in LPS and IFN-γ-induced RAW 264.7 murine macrophages. |
| Targets | NO | IFN-γ | TNF-α | NF-kB |
Rubiyunnanin C Dilution Calculator
Rubiyunnanin C Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.2064 mL | 6.032 mL | 12.064 mL | 24.1281 mL | 30.1601 mL |
| 5 mM | 0.2413 mL | 1.2064 mL | 2.4128 mL | 4.8256 mL | 6.032 mL |
| 10 mM | 0.1206 mL | 0.6032 mL | 1.2064 mL | 2.4128 mL | 3.016 mL |
| 50 mM | 0.0241 mL | 0.1206 mL | 0.2413 mL | 0.4826 mL | 0.6032 mL |
| 100 mM | 0.0121 mL | 0.0603 mL | 0.1206 mL | 0.2413 mL | 0.3016 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Cyclopeptides from Rubia schumanniana].[Pubmed:23236752]
Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(17):2563-70.
OBJECTIVE: To separate and identify cyclopeptides of tubers of Rubia schumanniana. METHOD: The 70% methanol extracts from tubers of Rubia schumanniana were separated and purified by silica gel, RP-18, Sephedax LH-20 and HPLC. Their structures were identified by spectral analysis. RESULT: Nine cyclopeptides were separated and identified as RA- II (1), RA-V (2), RA-VIII (3), Rubiyunnanin C (4), RA-X (5), RY-II (6), RA- I (7), RA-XIII (8) and RA-XIII-OMe (9), respectively. CONCLUSION: All of nine cyclopeptides were separated from R. schumanniana for the first time.
Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappaB activation.[Pubmed:21044847]
Bioorg Med Chem. 2010 Dec 1;18(23):8226-34.
Six new (rubiyunnanins C-H, 1-6) and five known (7-11) cyclic hexapeptides were isolated from the roots of Rubiayunnanensis (Franch.) Diels. The structures and stereochemistry of 1-6 were established by extensive spectroscopic analyses and chemical methods. All compounds (1-11) not only exhibited cytotoxic activities against a panel of eleven cancer cell lines with IC(5)(0) values ranging from 0.001 to 56.24 muM, but also exerted inhibitory activities against nitric oxide (NO) production in LPS and IFN-gamma-induced RAW 264.7 murine macrophages with IC(5)(0) values ranging from 0.05 to 12.68 muM. Furthermore, this is the first time it is being reported that compounds 2 and 7-10 significantly inhibited TNF-alpha-induced NF-kappaB activation in HEK-293-NF-kappaB luciferase stable cells with IC(5)(0) values of 35.07, 0.03, 1.69, 12.64 and 1.18 muM, respectively.
