Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN5666 | 3-Epicorosolic acid |
| 1. 3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction. 2. 3-Epicorosolic acid shows both potent α-glucosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitory activities with IC50 values of 30.18 and 4.08 μg/ml respectively. 3. 3-Epicorosolic acid shows mixed type inhibition against PTP1B, while it shows uncompetitive inhibition against α-glucosidase; suggests that it has potential antidiabetic activity. 4. 3-Epicorosolic acid possesses the ability to inhibit the expression of one or more inflammatory genes induced by 12-O-tetradecanoylphorbol-13 acetate in mouse skin, it has potential anti-inflammatory activities as well as cancer chemopreventive activity. | |
| BCN5667 | Lochnerine |
| 1. Lochnerine shows potent vasorelaxant activity. 2. Lochnerine shows some antitumor activity, it can bring about complete inhibition of cell growth in P388 leukemia cells in vitro. | |
| BCN5668 | Vindorosine |
| 1. Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular smooth muscles. | |
| BCN5669 | Angelicin |
| Angelicin has anti-cancer, antiviral, and anti-inflammatory activities; it regulates LPS-induced inflammation via inhibiting MAPK/NF-κB pathways. Angelicin is a powerful inducer of erythroid differentiation and -globin mRNA accumulation of human leukemia K562 cells, it is a potential therapeutic approach in hematological disorders, including -beta-thalassemia and sickle cell anemia. | |
| BCN5670 | Erysotramidine |
| 1. (+)-Erysotramidine shows potent dosedependant antifeedant activity at concentrations 3100 ppm. | |
| BCN5672 | Wedelolactone |
| Wedelolactone is a potent Î2-arrestin-biased G protein-coupled receptor-35 (GPR35) agonist, GPR35 has been shown to be a target of the asthma drugs cromolyn disodium and nedocromil sodium. Wedelolactone has anti-inflammatory, growth inhibitory, anti-cancer, anti-fibrotic, and pro-apoptotic effects. Wedelolactone stimulates ER genomic and non-genomic signalling pathways; it can significantly inhibit the activation of LX-2 cells, the underlying mechanisms of which included inducing Bcl-2 family involved apoptosis, up-regulating phosphorylated status of ERK and JNK expressions, and inhibiting NF-κB mediated activity. | |
| BCN5673 | gamma-Fagarine |
| 1. gamma-Fagarine possesses moderate levels of anti-HCV activities with IC₅₀ values being 20.4 ± 0.4 ug/ml, respectively. 2. gamma-Fagarine has sister chromatid exchanges (SCEs)-inducing activity, it induces SCEs in human lymphocyte cultures in a dose-dependent manner. 3. gamma-Fagarine and dictamnine are mutagenic in strain TA100 and TA98 with S9 mix, they have specific activities (His+/microgram) of about 50-70 revertant colonies in strain TA100, while in strain TA98 there are about 30-50 revertant colonies. | |
| BCN5676 | Quercetin 3-O-robinobioside |
| 1.Quercetin-3-O-robinobioside is a quercetin-derived flavonol, exhibits antioxidant activities. 2.Quercetin-3-O-robinobioside exhibits in-vitro inhibitory activities against leukemia K562 cells. | |
