Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN5591 | Pinoresinol |
| Pinoresinol has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, to increase nitric oxide release and to reduce oxidative stress preserving pial blood flow distribution; it may exert pharmacologically interesting effects via modulation of the insulin-like signalling pathway in C. elegans. Pinoresinol causes an upregulation of the CDK inhibitor p21(WAF1/Cip1) both at mRNA and protein levels, inhibits NF-kappaB and activating protein 1 (AP-1). | |
| BCN5592 | Butein |
| Butein is a chelator of ferrous and copper ions, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR. Butein can inactivate PMA-activated AP-1, due to the blocking of JNK-mediated c-Jun phosphorylation through the inhibition of ATP binding. Butein has potent anticancer, anti-inflammatory, antioxidant activities, it also has a hypotensive effect, at least in part, via the inhibition of angiotensin converting enzyme. | |
| BCN5593 | Allitol |
| 1. Allitol is useful as a sweetener and the raw material for production of chemical compounds. 2. Allitol can be useful as a substrate for the production of L-form ketoses and aldoses. 3. Allitol may be an important intermediate for the preparation of some medicines against diabetes, cancer, and viral infections, including AIDS. | |
| BCN5594 | vibo-Quercitol |
| (-)-vibo-Quercitol is a carbaglycosylamine glycosidase inhibitor. | |
| BCN5595 | D-arabinitol |
| D-arabinitol is a marker for the diagnosis of disseminated candidiasis and for monitoring response to antifungal therapy. | |
| BCN5596 | Robinetin |
| 1. Robinetin has antioxidant and antiradical activities, inhibits EYPC membrane lipid peroxidation and HbA glycosylation with high efficiency. 2. Robinetin leads to the occurrence of positive induced circular dichroism (ICD) bands in the near ultra-violet (UV) region. 3. Robinetin has anti-mutagenesis and anti-promotion effects, diminishes ornithine decarboxylase activity induction at 6 h after 12-O-tetradecanoyl phorbol-13-acetate. | |
| BCN5597 | Epicatechin |
| (−)Epicatechin is a flavonoid present in cocoa, green tea and red wine. It is a strong antioxidant, has antinociceptive, insulin mimic actions and improves heart health; it has the potential to increase CREB-regulated gene expression and increase GluR2 levels and thus modulate neurotransmission, plasticity and synaptogenesis. (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM; it inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB. | |
| BCN5598 | Kaempferide |
| Kaempferide has a variety of effects including anti-carcinogenic, anti-inflammatory, anti-oxidant, anti-bacterial and anti-viral properties.it can protect DNA from radiation induced lesions resulting from radiation exposures under in vitro and ex vivo conditions. | |
