Hot Natural Products & Bioactive Compounds

1. Decursinol angelate has anti-tumor activity.
2. Decursinol angelate inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway.
3. Decursinol angelate has protective effects against amyloid β-protein-induced oxidative stress in the PC12 cell line.
4. Decursinol angelate has anti-inflammatory effects, it suppresses invasion and inflammatory activation of cancer cells through modulation of PI3K/AKT, ERK and NF-kappaB, its anti-inflammatory activity may contribute to its anti-cancer activity.
5. Decursinol angelate has in vitro and in vivo antifungal activity against Magnaporthe oryzae, the causal agent of rice blast.
6. Decursinol angelate possesses not only the anti-oxidant, but also the hepatoprotective activities in rats.
7. Decursinol angelate improves wound healing by upregulating the expression of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors.

16beta,17-Dihydroxy-ent-kaurane-19-oic acid as an anti-HIV principle, it showed significant activity against HIV replication in H9 lymphocyte cells with an EC50 value of 0.8 microgram/mL. It also possesses the activities of decompression and blood viscosity depression.

1. Ilexgenin A has ability to regulate lipid profile and protect the liver against high fat diet (HFD) -induced impairment.
2. Ilexgenin A ameliorates hepatic insulin signaling and gluconeogenesis by regulating lipolysis in white adipose tissue (WAT).
3. Ilexgenin A exerts anti-inflammation and anti-angiogenesis effects through inhibition of STAT3 and PI3K pathways and exhibits synergistic effects with Sorafenib on hepatoma growth.
4. Ilexgenin A has anti-atherosclerotic activity, it shows reduction of atherosclerosis in apolipoprotein E deficient mice.
5. Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner, it is useful in the management of cardiovascular diseases in obesity.
6. Ilexgenin A could be regarded as a promising agent for the treatment of melanoma, it exerts anti-melanoma activity by arresting the cell cycle at G0/G1 and regulating IL-6 and TNF-α production.

1. Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure.
2. Marinobufagenin can induce proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5.
3. Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy.
4. Marinobufagenin, an endogenous ligand of alpha-1 sodium pump, is a marker of congestive heart failure severity.

1. Neocurdione is an attachment inhibitor against the blue mussel, Mytilus edulis galloprovincialis.
2. Neocurdione shows a protective effect against D-GalN/tumor necrosis factor-alpha-induced liver injury in mice at a dose of 50 mg/kg p.o.

1. Segetalin A has estrogen-like activity.

1. Tenuifoliside B is a target lactate dehydrogenase inhibitor.
2. Tenuifoliside B has cognitive improving and cerebral protective effects. it can inhibit potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment in mice.

Honokiol has antibacterial, anti-angiogenesis, antidepressant-like, antioxidant, anti-inflammatory and anti-cancer effects. It inhibited the activation of Akt and enhances the phosphorylation of ERK1/ERK2. It can improve learning, memory impairments and neuroinflammatory processes induced by SCOP in mice, by inhibition of AChE activity.