Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN5571 | Tetrahydroamentoflavone |
| 1. (2S,2″S )-Tetrahydroamentoflavone exerts its antioxidant activity in vitro through metal-chelating, and radical-scavenging, which is via donating a hydrogen atom (H61) and an electron (e). 2. Tetrahydroamentoflavone is a potent XO inhibitor, may be considered as a drug candidate or chemopreventive agent. 3. Tetrahydroamentoflavone has anti-inflammatory effects, it shows in vitro cyclooxygenase (COX) inhibition activity ( an IC(50) value of 29.5 microM (COX-1) and 40.5% inhibition at 100 microg/mL (COX-2)). | |
| BCN5572 | Kaempferitrin |
| Kaempferitrin exerts immunostimulatory, antidepressant-like , antiosteoporotic , cytotoxic and antitumor effects, the general mechanisms include cell cycle arrest in G1 phase and apoptosis via intrinsic pathway in a caspase dependent pathway. Kaempferitrin is an acute lowering effect on blood glucose in diabetic rats and to stimulate the glucose uptake percentile, as efficiently as insulin in muscle from normal rats. | |
| BCN5573 | Afzelin |
| Afzelin has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced damage by a combination of UV-absorbing and cellular activities. Afzelin has potenial anti-cancer activity against prostate cancer, the activity is due to inhibition of LIM domain kinase 021 expression, it can inhibit the proliferation of LNCaP and PC302cells, and block the cell cycle in the G002phase. Afzelin can attenuate asthma phenotypes is based on reduction of Th2 cytokine via inhibition of GATA-binding protein 3 transcription factor, which is the master regulator of Th2 cytokine differentiation and production. | |
| BCN5574 | Imperatorin |
| Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol); it is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM. Imperatorin is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle. Imperatorin has anticonvulsant, anti-inflammatory, anti-oxidant, neuroprotection, and anti-cancer effects, it also has been used in herbal formulations for the treatment of hypertension and cardiovascular diseases. Imperatorin dampens neuronal excitability by inhibiting voltage-gated Na + channels (VGSC), and blocks the HSP27 and HSP72 gene expression. | |
| BCN5575 | Sarpagine |
| 1. Sarpagine is effective in reversing multidrug-resistance (MDR) in vincristine-resistant KB cells. | |
| BCN5577 | Ajmalicine |
| 1. Ajmalicine, also known as δ-yohimbine or raubasine, is an antihypertensive drug used in the treatment of high blood pressure. | |
| BCN5578 | Isorauhimbine |
| 1.3-Epi-alpha-yohimbine(Isorauhimbine) has alpha adrenoceptor blocking activities, has cardiovascular effects. | |
| BCN5579 | Sphondin |
| 1. Sphondin possesses an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells through suppression of NF-kappaB activity, it may have the therapeutic potential as an anti-inflammatory drug on airway inflammation. 2. Sphondin, 8-methoxypsoralen, and khellin have delayed phototoxic effects inAedes aegypti. 3. Sphondin has NO production inhibitory activity, due to the effect of iNOS expression, it may act as a potent inhibitor of NO production under tissue-damaging inflammatory conditions. 4. Sphondin may have anticonvulsant activity. 5. Sphondin shows anti-proliferative activity and causes G2/M arrest at concentrations of 0.05-15.0 uM, it may have anti-tumor effects. | |
