NeocurdioneCAS# 108944-67-8 |
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| Cas No. | 108944-67-8 | SDF | Download SDF |
| PubChem ID | 24836956 | Appearance | Powder |
| Formula | C15H24O2 | M.Wt | 236.4 |
| Type of Compound | Sesquiterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3R,6Z,10S)-6,10-dimethyl-3-propan-2-ylcyclodec-6-ene-1,4-dione | ||
| SMILES | CC1CCC=C(CC(=O)C(CC1=O)C(C)C)C | ||
| Standard InChIKey | KDPFMRXIVDLQKX-BLJGWETHSA-N | ||
| Standard InChI | InChI=1S/C15H24O2/c1-10(2)13-9-14(16)12(4)7-5-6-11(3)8-15(13)17/h6,10,12-13H,5,7-9H2,1-4H3/b11-6-/t12-,13+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The rhizomes of Curcuma zedoaria
| Description | 1. Neocurdione is an attachment inhibitor against the blue mussel, Mytilus edulis galloprovincialis. 2. Neocurdione shows a protective effect against D-GalN/tumor necrosis factor-alpha-induced liver injury in mice at a dose of 50 mg/kg p.o. |
| Targets | NO | TNF-α | Caspase |
Neocurdione Dilution Calculator
Neocurdione Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.2301 mL | 21.1506 mL | 42.3012 mL | 84.6024 mL | 105.753 mL |
| 5 mM | 0.846 mL | 4.2301 mL | 8.4602 mL | 16.9205 mL | 21.1506 mL |
| 10 mM | 0.423 mL | 2.1151 mL | 4.2301 mL | 8.4602 mL | 10.5753 mL |
| 50 mM | 0.0846 mL | 0.423 mL | 0.846 mL | 1.692 mL | 2.1151 mL |
| 100 mM | 0.0423 mL | 0.2115 mL | 0.423 mL | 0.846 mL | 1.0575 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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9-Oxo-neoprocurcumenol from Curcuma aromatica (Zingiberaceae) as an attachment inhibitor against the blue mussel, Mytilus edulis galloprovincialis.[Pubmed:12784640]
Biosci Biotechnol Biochem. 2003 Apr;67(4):911-3.
Neocurdione, isoprocurcumenol, and a new sesquiterpene, 9-oxo-neoprocurcumenol, were isolated from fresh rhizomes of Curcuma aromatica and Curcuma zedoaria (Zingiberaceae) as attachment inhibitors against the blue mussel, Mytilus edulis galloprovincialis. The structures of these compounds were elucidated on the basis of spectroscopic evidence.
[Studies on chemical constituents of Curcuma aromatica salisb].[Pubmed:12212100]
Zhongguo Zhong Yao Za Zhi. 2000 Mar;25(3):163-5.
OBJECTIVE: To study the effective ingredients of Curcuma aromatica. METHOD: Solvent extraction was used. The constituents were isolated with resin D-101 silica gel column and thin-layer chromatography, and the structures were elucidated by physico-chemical properties and spectral analysis. RESULT: Curdione, Neocurdione, curcumol, tetramethylpyrazine and (R)-(+)-1,2-hexadecanediol were isolated from C. aromatica. CONCLUSION: Neocurdione and (R)-(+)-1,2-hexadecanediol were isolated from C. aromatica for the first time, and was isolated from Curcuma and reported for the first time.
Neocurdione is a hepatoprotective sesquiterpene isolated from Curcuma zedoaria rhizome. Neocurdione exerts potent effect on D-galactosamine- (D-Gain) and lipopolysaccharide- (LPS) induced acute liver injury in mice.
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