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2-Methylaminoethanol

CAS# 109-83-1

2-Methylaminoethanol

Catalog No. BCN1758----Order now to get a substantial discount!

Product Name & Size Price Stock
2-Methylaminoethanol: 5mg Please Inquire In Stock
2-Methylaminoethanol: 10mg Please Inquire In Stock
2-Methylaminoethanol: 20mg Please Inquire Please Inquire
2-Methylaminoethanol: 50mg Please Inquire Please Inquire
2-Methylaminoethanol: 100mg Please Inquire Please Inquire
2-Methylaminoethanol: 200mg Please Inquire Please Inquire
2-Methylaminoethanol: 500mg Please Inquire Please Inquire
2-Methylaminoethanol: 1000mg Please Inquire Please Inquire

Quality Control of 2-Methylaminoethanol

Number of papers citing our products

Chemical structure

2-Methylaminoethanol

3D structure

Chemical Properties of 2-Methylaminoethanol

Cas No. 109-83-1 SDF Download SDF
PubChem ID 8016 Appearance Cryst.
Formula C3H9NO M.Wt 75.11
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 2-(methylamino)ethanol
SMILES CNCCO
Standard InChIKey OPKOKAMJFNKNAS-UHFFFAOYSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 2-Methylaminoethanol

The seeds of Lens culinaris

Biological Activity of 2-Methylaminoethanol

In vitro

Effect of Amino Alcohols and their Phosphoryl Compounds on the Growth of Experimentally Transplantable Cancer.[Reference: WebLink]

Chemical & Pharmaceutical Bulletin, 2008,8 (10) :900-903


METHODS AND RESULTS:
Effect of 2-aminoethanol, 2-Methylaminoethanol , 2-dimethylaminoethanol, choline, and their phosphorylated compounds on the growth of Ehrlich solid tumor and in vitro growth of Yoshida sarcoma cells was examined and following facts were revealed. 1) On the Ehrlich tumor, 2-aminoethyl dihydrogenphosphate and 2-methylaminoethyl dihydrogenphosphate had a growth-promoting effect while the others had no effect. 2) 2-Aminoethanol and 2-aminoethyl dihydrogenphosphate were inhibitive to the in vitro growth of Yoshida sarcoma cells but others had no effect.
CONCLUSIONS:
3) There was entirely no difference in the lipids between the groups administered and not administered 2-aminoethyl dihydrogenphosphate.

Protocol of 2-Methylaminoethanol

Structure Identification
Journal of Molecular Spectroscopy,1975,56(2):229-238.

Hydrogen bonding and conformational equilibrium of 2-methylaminoethanol by microwave spectroscopy[Reference: WebLink]


METHODS AND RESULTS:
From its microwave spectrum, 2-Methylaminoethanol is found to exist in two rotameric forms.

2-Methylaminoethanol Dilution Calculator

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2-Methylaminoethanol Molarity Calculator

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Preparing Stock Solutions of 2-Methylaminoethanol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 13.3138 mL 66.569 mL 133.1381 mL 266.2761 mL 332.8452 mL
5 mM 2.6628 mL 13.3138 mL 26.6276 mL 53.2552 mL 66.569 mL
10 mM 1.3314 mL 6.6569 mL 13.3138 mL 26.6276 mL 33.2845 mL
50 mM 0.2663 mL 1.3314 mL 2.6628 mL 5.3255 mL 6.6569 mL
100 mM 0.1331 mL 0.6657 mL 1.3314 mL 2.6628 mL 3.3285 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 2-Methylaminoethanol

Molecular Dynamics Study of the Solution Structure, Clustering, and Diffusion of Four Aqueous Alkanolamines.[Pubmed:29446633]

J Phys Chem B. 2018 Mar 15;122(10):2769-2778.

CO2 sequestration from anthropogenic resources is a challenge to the design of environmental processes at a large scale. Reversible chemical absorption by amine-based solvents is one of the most efficient methods of CO2 removal. Molecular simulation techniques are very useful tools to investigate CO2 binding by aqueous alkanolamine molecules for further technological application. In the present work, we have performed detailed atomistic molecular dynamics simulations of aqueous solutions of three prototype amines: monoethanolamine (MEA) as a standard, 3-aminopropanol (MPA), 2-Methylaminoethanol (MMEA), and 4-diethylamino-2-butanol (DEAB) as potential novel CO2 absorptive solvents. Solvent densities, radial distribution functions, cluster size distributions, hydrogen-bonding statistics, and diffusion coefficients for a full range of mixture compositions have been obtained. The solvent densities and diffusion coefficients from simulations are in good agreement with those in the experiment. In aqueous solution, MEA, MPA, and MMEA molecules prefer to be fully solvated by water molecules, whereas DEAB molecules tend to self-aggregate. In a range from 30/70-50/50 (w/w) alkanolamine/water mixtures, they form a bicontinuous phase (both alkanolamine and water are organized in two mutually percolating clusters). Among the studied aqueous alkanolamine solutions, the diffusion coefficients decrease in the following order MEA > MPA = MMEA > DEAB. With an increase of water content, the diffusion coefficients increase for all studied alkanolamines. The presented results are a first step for process-scale simulation and provide important qualitative and quantitative information for the design and engineering of efficient new CO2 removal processes.

The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels.[Pubmed:18923087]

J Pharmacol Exp Ther. 2009 Jan;328(1):351-61.

The novel endocannabinoid-like lipid N-arachidonoyl L-serine (ARA-S) causes vasodilation through both endothelium-dependent and -independent mechanisms. We have analyzed the vasorelaxant effect of ARA-S in isolated vascular preparations and its effects on Ca(2+)-activated K(+) currents in human embryonic kidney cells stably transfected with the alpha-subunit of the human, large conductance Ca(+)-activated K(+) (BK(Ca)) channel [human embryonic kidney (HEK) 293hSlo cells]. ARA-S caused relaxation of rat isolated, intact and denuded, small mesenteric arteries preconstricted with (R)-(-)-1-(3-hydroxyphenyl)-2-Methylaminoethanol hydrochloride (pEC(50), 5.49 and 5.14, respectively), whereas it caused further contraction of vessels preconstricted with KCl (pEC(50), 5.48 and 4.82, respectively). Vasorelaxation by ARA-S was inhibited by 100 nM iberiotoxin. In human embryonic kidney cells stably transfected with the alpha-subunit of the human BK(Ca) channel cells, ARA-S and its enantiomer, N-arachidonoyl-D-serine, enhanced the whole-cell outward K(+) current with similar potency (pEC(50), 5.63 and 5.32, respectively). The potentiation was not altered by the beta(1) subunit or mediated by ARA-S metabolites, stimulation of known cannabinoid receptors, G proteins, protein kinases, or Ca(2+)-dependent processes; it was lost after patch excision or after membrane cholesterol depletion but was restored after cholesterol reconstitution. BK(Ca) currents were also enhanced by N-arachidonoyl ethanolamide (pEC(50), 5.27) but inhibited by another endocannabinoid, O-arachidonoyl ethanolamine (pIC(50), 6.35), or by the synthetic cannabinoid O-1918 [(-)-1,3-dimethoxy-2-(3-3,4-trans-p-menthadien-(1,8)-yl)-orcinol] (pIC(50), 6.59), which blocks ARA-S-induced vasodilation. We conclude the following. 1) ARA-S directly activates BK(Ca) channels. 2) This interaction does not involve cannabinoid receptors or cytosolic factors but is dependent on the presence of membrane cholesterol. 3) Direct BK(Ca) channel activation probably contributes to the endothelium-independent component of ARA-S-induced mesenteric vasorelaxation. 4) O-1918 is a BK(Ca) channel inhibitor.

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