Mauritianin

CAS# 109008-28-8

Mauritianin

Catalog No. BCN2932----Order now to get a substantial discount!

Product Name & Size Price Stock
Mauritianin: 5mg $322 In Stock
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Quality Control of Mauritianin

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Chemical structure

Mauritianin

3D structure

Chemical Properties of Mauritianin

Cas No. 109008-28-8 SDF Download SDF
PubChem ID 5748188 Appearance Yellow powder
Formula C33H40O19 M.Wt 740.7
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 5,7-dihydroxy-3-[(2R,3R,4S,5S,6R)-5-hydroxy-6-(hydroxymethyl)-3,4-bis[[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy]oxan-2-yl]oxy-2-(4-hydroxyphenyl)chromen-4-one
SMILES CC1C(C(C(C(O1)OC2C(C(OC(C2OC3C(C(C(C(O3)C)O)O)O)OC4=C(OC5=CC(=CC(=C5C4=O)O)O)C6=CC=C(C=C6)O)CO)O)O)O)O
Standard InChIKey AEOBNVBHRFQADS-DNDPRTLXSA-N
Standard InChI InChI=1S/C33H40O19/c1-10-19(38)23(42)25(44)31(46-10)50-28-21(40)17(9-34)49-33(30(28)52-32-26(45)24(43)20(39)11(2)47-32)51-29-22(41)18-15(37)7-14(36)8-16(18)48-27(29)12-3-5-13(35)6-4-12/h3-8,10-11,17,19-21,23-26,28,30-40,42-45H,9H2,1-2H3/t10-,11-,17+,19-,20-,21-,23+,24+,25+,26+,28-,30+,31-,32-,33+/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Mauritianin

The herbs of Hypericum japonicum Thunb.

Biological Activity of Mauritianin

Description1. Mauritianin and (+)-syringaresinol as new topoisomerase I inhibitors. 2. Mauritianin has statistically significant cytoprotective activity similar to that of silymarin, tested at 60 ug/mL.
TargetsTopoisomerase

Mauritianin Dilution Calculator

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Mauritianin Molarity Calculator

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Preparing Stock Solutions of Mauritianin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.3501 mL 6.7504 mL 13.5007 mL 27.0015 mL 33.7519 mL
5 mM 0.27 mL 1.3501 mL 2.7001 mL 5.4003 mL 6.7504 mL
10 mM 0.135 mL 0.675 mL 1.3501 mL 2.7001 mL 3.3752 mL
50 mM 0.027 mL 0.135 mL 0.27 mL 0.54 mL 0.675 mL
100 mM 0.0135 mL 0.0675 mL 0.135 mL 0.27 mL 0.3375 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Mauritianin

Flavoalkaloids and Flavonoids from Astragalus monspessulanus.[Pubmed:26558405]

J Nat Prod. 2015 Nov 25;78(11):2565-71.

A new flavonol tetraglycoside, quercetin-3-O-[alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->6)]- beta-D-galactopyranosyl]-7-O-beta-D-glucopyranoside (1), and two new flavonol alkaloids, N-(8-methylquercetin-3-O-[alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosy l-(1-->6)]-beta-D-galactopyranosyl])-3-hydroxypiperidin-2-one (2) and N-(8-methylkaempferol-3-O-[alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranos yl-(1-->6)]-beta-D-galactopyranosyl])-3-hydroxypiperidin-2-one (3), were isolated from the aerial parts of Astragalus monspessulanus ssp. monspessulanus. Two rare flavonoids with an unusual 3-hydroxy-3-methylglutaric acid moiety, quercetin-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[6-O-(3-hydroxy-3-methylglutaryl)-b eta-D-galactopyranoside (4) and kaempferol-3-O-alpha-L-rhamnopyranosyl-(1-->2)-[6-O-(3-hydroxy-3-methylglutaryl)- beta-D-galactopyranoside (5), were isolated from the aerial parts of A. monspessulanus ssp. illyricus. In addition, the eight known flavonoids alangiflavoside (6), alcesefoliside (7), Mauritianin (8), quercetin-3-beta-robinobioside (9), cosmosine (10), apigenin-4'-O-glucoside (11), trifolin (12), and rutin (13) were isolated from aerial parts of A. monspessulanus ssp. monspessulanus. Their structures were elucidated via NMR and HRESIMS data. In a model that tested t-BuOOH-induced oxidative stress on isolated rat hepatocytes, flavonoids 1-13 had statistically significant cytoprotective activity similar to that of silymarin, tested at 60 mug/mL. The most prominent effects were observed for flavonoids 1, 4, 7, and 12.

DNA topoisomerase I inhibitors from Rinorea anguifera.[Pubmed:15664863]

Bioorg Med Chem Lett. 2005 Feb 1;15(3):813-6.

An organic extract prepared from Rinorea anguifera was investigated in order to identify the natural principle(s) responsible for stabilization of a topoisomerase I-DNA covalent binary complex. Bioassay-guided fractionation resulted in the isolation of Mauritianin and (+)-syringaresinol as new topoisomerase I inhibitors, and also of the known inhibitor camptothecin.

Description

Mauritianin is a kaempferol glycoside isolated from the flowers and leaves of Acalypha indica. Mauritianin is a topoisomerase I inhibitor.

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