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Schizanthine E

CAS# 109031-04-1

Schizanthine E

Catalog No. BCN1937----Order now to get a substantial discount!

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Quality Control of Schizanthine E

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Chemical structure

Schizanthine E

3D structure

Chemical Properties of Schizanthine E

Cas No. 109031-04-1 SDF Download SDF
PubChem ID 134715027 Appearance Oil
Formula C26H38N2O7 M.Wt 490.59
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 1-O-[(3R,6R)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-6-yl] 4-O-[(3R,6R)-8-methyl-6-[(E)-2-methylbut-2-enoyl]oxy-8-azabicyclo[3.2.1]octan-3-yl] 2-methylidenebutanedioate
SMILES CC=C(C)C(=O)OC1CC2CC(CC1N2C)OC(=O)CC(=C)C(=O)OC3CC4CC(CC3N4C)O
Standard InChIKey KOHKWULQOJFCAA-XWKQAIQLSA-N
Standard InChI InChI=1S/C26H38N2O7/c1-6-14(2)25(31)34-23-11-17-9-19(13-21(23)28(17)5)33-24(30)7-15(3)26(32)35-22-10-16-8-18(29)12-20(22)27(16)4/h6,16-23,29H,3,7-13H2,1-2,4-5H3/b14-6+/t16?,17?,18-,19-,20?,21?,22-,23-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Protocol of Schizanthine E

Structure Identification
Journal of Natural Products, 2011, 74(1):50-53.

Schizanthines N, O, and P, Tropane Alkaloids from the Aerial Parts of Schizanthus tricolor.[Reference: WebLink]


METHODS AND RESULTS:
Three tropane alkaloids, named schizanthines N, O, and P (1-3), have been isolated from the crude alkaloid extract of the endemic Chilean plant Schizanthus tricolor. On the basis of extensive NMR studies and MS fragmentation analysis, their structures were determined to be 3α-(E)-4-hydroxysenecioyloxy-6β-angeloyloxytropane (1), 3α-(E)-4-hydroxysenecioyloxy-6β-senecioyloxytropane (2), and 3α-mesaconyloxy-6β-senecioyloxytropane (3).
CONCLUSIONS:
Compounds 1 and 2 are the first isomeric alkaloids in the tropane series possessing a hydroxysenecioyl substituent as an esterifying moiety.

Schizanthine E Dilution Calculator

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Schizanthine E Molarity Calculator

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Preparing Stock Solutions of Schizanthine E

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0384 mL 10.1918 mL 20.3836 mL 40.7672 mL 50.959 mL
5 mM 0.4077 mL 2.0384 mL 4.0767 mL 8.1534 mL 10.1918 mL
10 mM 0.2038 mL 1.0192 mL 2.0384 mL 4.0767 mL 5.0959 mL
50 mM 0.0408 mL 0.2038 mL 0.4077 mL 0.8153 mL 1.0192 mL
100 mM 0.0204 mL 0.1019 mL 0.2038 mL 0.4077 mL 0.5096 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Schizanthine E

Functional studies of E. faecalis RNase J2 and its role in virulence and fitness.[Pubmed:28384222]

PLoS One. 2017 Apr 6;12(4):e0175212.

Post-transcriptional control provides bacterial pathogens a method by which they can rapidly adapt to environmental change. Dual exo- and endonucleolytic activities of RNase J enzymes contribute to Gram-positive RNA processing and decay. First discovered in Bacillus subtilis, RNase J1 plays a key role in mRNA maturation and degradation, while the function of the paralogue RNase J2 is largely unknown. Previously, we discovered that deletion of the Enterococcus faecalis rnjB gene significantly attenuates expression of a major virulence factor involved in enterococcal pathogenesis, the Ebp pili. In this work, we demonstrate that E. faecalis rnjB encodes an active RNase J2, and that the ribonuclease activity of RNase J2 is required for regulation of Ebp pili. To further investigate how rnjB affects E. faecalis gene expression on a global scale, we compared transcriptomes of the E. faecalis strain OG1RF with its isogenic rnjB deletion mutant (DeltarnjB). In addition to Ebp pili regulation, previously demonstrated to have a profound effect on the ability of E. faecalis to form biofilm or establish infection, we identified that rnjB regulates the expression of several other genes involved in bacterial virulence and fitness, including gls24 (a virulence factor important in stress response). We further demonstrated that the E. faecalis RNase J2 deletion mutant is more sensitive to bile salt and greatly attenuated in in vivo organ infection as determined by an IV-sublethal challenge infection mouse model, indicating that E. faecalis RNase J2 plays an important role in E. faecalis virulence.

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