Home >> Research Area >>Coumarins>> Decursinol angelate

Decursinol angelate

CAS# 130848-06-5

Decursinol angelate

2D Structure

Catalog No. BCC9222----Order now to get a substantial discount!

Product Name & Size Price Stock
Decursinol angelate: 5mg $63 In Stock
Decursinol angelate: 10mg Please Inquire In Stock
Decursinol angelate: 20mg Please Inquire Please Inquire
Decursinol angelate: 50mg Please Inquire Please Inquire
Decursinol angelate: 100mg Please Inquire Please Inquire
Decursinol angelate: 200mg Please Inquire Please Inquire
Decursinol angelate: 500mg Please Inquire Please Inquire
Decursinol angelate: 1000mg Please Inquire Please Inquire

Quality Control of Decursinol angelate

3D structure

Package In Stock

Decursinol angelate

Number of papers citing our products

Chemical Properties of Decursinol angelate

Cas No. 130848-06-5 SDF Download SDF
PubChem ID 776123 Appearance White powder
Formula C19H20O5 M.Wt 328.4
Type of Compound Coumarins Storage Desiccate at -20°C
Synonyms Acutilobin
Solubility Soluble in DMSO and methanol; insoluble in water
Chemical Name [(3S)-2,2-dimethyl-8-oxo-3,4-dihydropyrano[3,2-g]chromen-3-yl] (Z)-2-methylbut-2-enoate
SMILES CC=C(C)C(=O)OC1CC2=C(C=C3C(=C2)C=CC(=O)O3)OC1(C)C
Standard InChIKey AGABNGOXUSXQDD-XKGFZTIGSA-N
Standard InChI InChI=1S/C19H20O5/c1-5-11(2)18(21)23-16-9-13-8-12-6-7-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/b11-5-/t16-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Decursinol angelate

The roots of Angelica gigas

Biological Activity of Decursinol angelate

Description1. Decursinol angelate has anti-tumor activity. 2. Decursinol angelate inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway. 3. Decursinol angelate has protective effects against amyloid β-protein-induced oxidative stress in the PC12 cell line. 4. Decursinol angelate has anti-inflammatory effects, it suppresses invasion and inflammatory activation of cancer cells through modulation of PI3K/AKT, ERK and NF-kappaB, its anti-inflammatory activity may contribute to its anti-cancer activity. 5. Decursinol angelate has in vitro and in vivo antifungal activity against Magnaporthe oryzae, the causal agent of rice blast. 6. Decursinol angelate possesses not only the anti-oxidant, but also the hepatoprotective activities in rats. 7. Decursinol angelate improves wound healing by upregulating the expression of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors.
TargetsVEGFR | JNK | ERK | Beta Amyloid | Nrf2 | NF-kB | SOD | EGFR | PI3K | Akt | Antifection

Decursinol angelate Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Decursinol angelate Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Decursinol angelate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.0451 mL 15.2253 mL 30.4507 mL 60.9013 mL 76.1267 mL
5 mM 0.609 mL 3.0451 mL 6.0901 mL 12.1803 mL 15.2253 mL
10 mM 0.3045 mL 1.5225 mL 3.0451 mL 6.0901 mL 7.6127 mL
50 mM 0.0609 mL 0.3045 mL 0.609 mL 1.218 mL 1.5225 mL
100 mM 0.0305 mL 0.1523 mL 0.3045 mL 0.609 mL 0.7613 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Decursinol angelate

Decursinol Angelate Inhibits LPS-Induced Macrophage Polarization through Modulation of the NFkappaB and MAPK Signaling Pathways.[Pubmed:30060484]

Molecules. 2018 Jul 27;23(8). pii: molecules23081880.

Inflammation is considered the root cause of various inflammatory diseases, including cancers. Decursinol angelate (DA), a pyranocoumarin compound obtained from the roots of Angelica gigas, has been reported to exhibit potent anti-inflammatory effects. In this study, the anti-inflammatory effects of DA on the MAP kinase and NFkappaB signaling pathways and the expression of pro-inflammatory cytokines were investigated in phorbol 12-myristate 13-acetate (PMA)-activated human promyelocytic leukemia (HL-60) and lipopolysaccharide (LPS)-stimulated macrophage (Raw 264.7) cell lines. PMA induced the activation of the MAP kinase-NFkappaB pathway and the production of pro-inflammatory cytokines in differentiated monocytes. Treatment with DA inhibited the activation of MAP kinases and the translocation of NFkappaB, and decreased the expression and exogenous secretion of IL-1beta and IL-6. Furthermore, LPS-stimulated Raw 264.7 cells were found to have increased expression of M1 macrophage-associated markers, such as NADPH oxidase (NOX) and inducible nitric oxide synthase (iNOS), and the M2 macrophage-associated marker CD11b. LPS also activated pro-inflammatory cytokines and Erk-NFkappaB. Treatment with DA suppressed LPS-induced macrophage polarization and the inflammatory response by blocking Raf-ERK and the translocation of NFkappaB in Raw 264.7 cells. Treatment with DA also inhibited the expression of pro-inflammatory cytokines, such as IL-1beta and IL-6, NOX, and iNOS in Raw 264.7 cells. These results suggest that DA has the potential to inhibit macrophage polarization and inflammation by blocking the activation of pro-inflammatory signals. These anti-inflammatory effects of DA may contribute to its potential use as a therapeutic strategy against various inflammation-induced cancers.

Description

Decursinol angelate, a cytotoxic and protein kinase C (PKC) activating agent from the root of Angelica gigas, possesses anti-tumor and anti-inflammatory activities.

Keywords:

Decursinol angelate,130848-06-5,Acutilobin,Natural Products, buy Decursinol angelate , Decursinol angelate supplier , purchase Decursinol angelate , Decursinol angelate cost , Decursinol angelate manufacturer , order Decursinol angelate , high purity Decursinol angelate

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: