Cerberic acid B

CAS# 1309362-77-3

Cerberic acid B

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Cerberic acid B: 5mg $799 In Stock
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Quality Control of Cerberic acid B

Number of papers citing our products

Chemical structure

Cerberic acid B

3D structure

Chemical Properties of Cerberic acid B

Cas No. 1309362-77-3 SDF Download SDF
PubChem ID 91886686 Appearance Powder
Formula C10H10O5 M.Wt 210.18
Type of Compound Phenylpropanoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name 3-[(2R)-2-carboxy-2-hydroxyethyl]benzoic acid
SMILES C1=CC(=CC(=C1)CC(C(=O)O)O)C(=O)O
Standard InChIKey QOJNCZPYJHQQOQ-MRVPVSSYSA-N
Standard InChI InChI=1S/C10H10O5/c11-8(10(14)15)5-6-2-1-3-7(4-6)9(12)13/h1-4,8,11H,5H2,(H,12,13)(H,14,15)/t8-/m1/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Cerberic acid B

The bark of Cerbera manghas

Biological Activity of Cerberic acid B

DescriptionStandard reference
In vitro

Phenylpropionic acid derivates from the bark of Cerbera manghas.[Pubmed: 20546844]

Fitoterapia. 2010 Oct;81(7):852-4.


METHODS AND RESULTS:
Two new phenylpropionic acid derivates, cerberic acid A (1) and Cerberic acid B (2), were isolated from the bark of Cerbera manghas. Their structures were established on the basis of spectroscopic methods including IR, ESI-FT-ICR-MS, 1D and 2D NMR.
CONCLUSIONS:
Primary bioassays showed that compound 1 possessed weak cytotoxic activity against HepG2, MCF-7, and HeLa cell lines with IC(50) values of 44.7, 52.3, 48.7 μg/ml, respectively.

Protocol of Cerberic acid B

Structure Identification
Separation Science\s&\stechnology, 2015 , 50 (15) :2360-2366.

Separation and Purification of 15-Demethylplumieride, Cerberic Acid B, and Kaempferol-3-Rutinoside from Plumeria rubra ‘Acutifolia’ by High-Speed Counter-Current Chromatography[Reference: WebLink]


METHODS AND RESULTS:
Three compounds, 15-demethylplumieride (I), Cerberic acid B (II), and kaempferol-3-rutinoside (III) were successfully separated from the flowers of Plumeria rubra ‘Acutifolia’ by high-speed counter-current chromatography (HSCCC) for the first time. The crude extract from Plumeria rubra ‘Acutifolia’ was treated with D101 macroporous resin and divided into two parts: fraction 1 (15% ethanol eluent) and fraction 2 (30% ethanol eluent). Two hundred and thirty milligrams of fraction 1 were separated by HSCCC with the solvent system of n -butanol-methanol-water (4:0.5:4, v/v/v), yielding 17 mg of I and 28 mg of II. One hundred and thirty-five milligrams of fraction 2 were separated by HSCCC with the solvent system of ethyl acetate- n -butanol-water (4.4:0.6:5, v/v/v), yielding 7 mg of III. The purities of the three compounds were determined by HPLC-DAD as 96.04%, 98.38%, and 97.97%, respectively.
CONCLUSIONS:
Their structures were identified by UV, MS, and NMR. The established methods were simple, fast, and convenient, which can be applied to the preparation of reference substances for bioactivity, quality control, fingerprint analysis, and other research of Plumeria rubra ‘Acutifolia’.

Cerberic acid B Dilution Calculator

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Cerberic acid B Molarity Calculator

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Preparing Stock Solutions of Cerberic acid B

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.7578 mL 23.7891 mL 47.5783 mL 95.1565 mL 118.9457 mL
5 mM 0.9516 mL 4.7578 mL 9.5157 mL 19.0313 mL 23.7891 mL
10 mM 0.4758 mL 2.3789 mL 4.7578 mL 9.5157 mL 11.8946 mL
50 mM 0.0952 mL 0.4758 mL 0.9516 mL 1.9031 mL 2.3789 mL
100 mM 0.0476 mL 0.2379 mL 0.4758 mL 0.9516 mL 1.1895 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Cerberic acid B

Phenylpropionic acid derivates from the bark of Cerbera manghas.[Pubmed:20546844]

Fitoterapia. 2010 Oct;81(7):852-4.

Two new phenylpropionic acid derivates, cerberic acids A (1) and B (2), were isolated from the bark of Cerbera manghas. Their structures were established on the basis of spectroscopic methods including IR, ESI-FT-ICR-MS, 1D and 2D NMR. Primary bioassays showed that compound 1 possessed weak cytotoxic activity against HepG2, MCF-7, and HeLa cell lines with IC(50) values of 44.7, 52.3, 48.7 mug/ml, respectively.

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