Hot Products
Hot products from BioCrick which is a professional high-purity natural products manufacturer are well known to scientists around the world because of their high purity and stability. Each product is a chemical compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life.Natural products remain the best sources of drugs and drug leads, and this remains true today despite the fact that many pharmaceutical companies have deemphasized natural products research in favor of HTP screening of combinatorial libraries during the past 2 decades. From 1940s to date, 131 (74.8%) out of 175 small molecule anticancer drugs are natural product-based/inspired, with 85 (48.6%) being either natural products or derived therefrom. From 1981 to date, 79 (80%) out of 99 small molecule anticancer drugs are natural product-based/inspired, with 53 (53%) being either natural products or derived therefrom. Among the 20 approved small molecule New Chemical Entities (NCEs) in 2010, a half of them are natural products.
Hot products from the professional high-purity natural products manufacturer
| Cat.No. | Product Name |
|---|---|
| BCN5609 | Rhododendrol |
| 1. (+)-Rhododendrol and epi-rhododendrin have anti-inflammatory effect, they can suppress the NO production by activated macrophages in vivo. 2. Rhododendrol is an inhibitor of melanin synthesis developed for lightening/whitening cosmetics, it can competitively inhibit mushroom tyrosinase and serve as a good substrate, while it also shows cytotoxicity against cultured human melanocytes at high concentrations sufficient for inhibiting tyrosinase. | |
| BCN5611 | Oleuropeic acid |
| 1. (+)-Oleuropeic acid shows potent in vitro antitumor-promoting activity, it also suppresses an in vivo two-stage carcinogenesis induced with nitric oxide and 12-O-tetradecanoyl phorbol 13-acetate (TPA) on mouse skin. | |
| BCN5612 | Orcinol |
| Orcinol glucoside is anxiolytic agent without sedative effect, it improves depressive behaviour in CUMS rats by downregulating HPA axis hyperactivity and increasing BDNF expression and ERK1/2 phosphorylation in the hippocampus. | |
| BCN5614 | Niranthin |
| 1. Niranthin exhibits anti-hepatitis B virus activity both in vitro and in vivo. 2. Niranthin exhibits antiinflammatory and antiallodynic actions which are probably mediated through its direct antagonistic action on the PAF receptor binding sites. 3. Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L. donovani and acts as a non-competitive inhibitor interacting with both subunits of the enzyme. | |
| BCN5616 | Oleanolic acid |
| Oleanolic acid is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor, anti-inflammatory, antioxidant, and antiviral properties. Oleanolic acid exhibits anti-HCV activity at least partly through suppressing HCV NS5B RdRp activity as a noncompetitive inhibitor; it induces the upregulation of miR-132, which serves as an important regulator of neurotrophic actions, mainly through the activation of the hippocampal BDNF-ERK-CREB signalling pathways; can be employed as a lead in the development of potent NO inhibitors. Oleanolic acid supplement ameliorates fructose-induced Adipo-IR in rats via the IRS-1/phosphatidylinositol 3-kinase/Akt pathway. | |
| BCN5618 | Glutinone |
| 1. Glutinone (IC50=24 microM) shows a significant effect on thromboxane B2 (TXB2)-release induced by calcium ionophore in human platelets. | |
| BCN5620 | Friedelanol |
| 1. Friedelanol and baccharis oxide can increase reactive oxygen intermediate (H2O2) production by macrophages at a concentration of 100 uM, suggests that they may display an immunomodulatory action. | |
| BCN5621 | Rosenonolactone |
| 1. Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin. | |
